Methods for tractography-driven surface registration of brain structures

Aleksandar Petrović, Stephen M. Smith, Ricarda A. Menke, Mark Jenkinson

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

7 Citations (Scopus)


Registration of brain structures should bring anatomically equivalent areas into correspondence which is usually done using information from structural MRI modalities. Correspondence can be improved by using other image modalities that provide complementary data. In this paper we propose and evaluate two novel surface registration algorithms which improve within-surface correspondence in brain structures. Both approaches use a white-matter tract similarity function (derived from probabilistic tractography) to match areas of similar connectivity patterns. The two methods differ in the way the deformation field is calculated and in how the multi-scale registration framework is implemented. We validated both algorithms using artificial and real image examples, in both cases showing high registration consistency and the ability to find differences in thalamic sub-structures between Alzheimer's disease and control subjects. The results suggest differences in thalamic connectivity predominantly in the medial dorsal parts of the left thalamus.

Original languageEnglish
Title of host publicationMedical Image Computing and Computer-Assisted Intervention - MICCAI 2009 - 12th International Conference, Proceedings
Number of pages8
EditionPART 1
Publication statusPublished or Issued - 1 Dec 2009
Externally publishedYes
Event12th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2009 - London, United Kingdom
Duration: 20 Sep 200924 Sep 2009

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
NumberPART 1
Volume5761 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349


Other12th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2009
CountryUnited Kingdom

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

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