Metformin Triggers PYY Secretion in Human Gut Mucosa

Emily W. Sun, Alyce M. Martin, David A. Wattchow, Dayan de Fontgalland, Philippa Rabbitt, Paul Hollington, Richard Young, Damien J. Keating

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The antidiabetic drug metformin causes weight loss, but the underlying mechanisms are unclear. Recent clinical studies show that metformin increases plasma levels of the anorectic gut hormone, peptide YY (PYY), but whether this is through a direct effect on the gut is unknown. Objective: We hypothesized that exposure of human gut mucosal tissue to metformin would acutely trigger PYY secretion. Design, Setting, Participants, and Interventions: Mucosal tissue was prepared from 46 human colonic and 9 ileal samples obtained after surgical resection and ex vivo secretion assays were performed. Tissue was exposed to metformin, as well as a series of other compounds as part of our mechanistic studies, in static incubations. Supernatant was sampled after 15 minutes.

Original languageEnglish
Article numberjcem_201802460
Pages (from-to)2668-2674
Number of pages7
JournalJournal of Clinical Endocrinology and Metabolism
Volume104
Issue number7
DOIs
Publication statusPublished - 12 Feb 2019
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Sun, E. W., Martin, A. M., Wattchow, D. A., de Fontgalland, D., Rabbitt, P., Hollington, P., ... Keating, D. J. (2019). Metformin Triggers PYY Secretion in Human Gut Mucosa. Journal of Clinical Endocrinology and Metabolism, 104(7), 2668-2674. [jcem_201802460]. https://doi.org/10.1210/jc.2018-02460