Metabolic profiling of pregnancy: cross-sectional and longitudinal evidence

Qin Wang, Peter Würtz, Kirsi Auro, Ville-Petteri Makinen, Antti J Kangas, Pasi Soininen, Mika Tiainen, Tuulia Tynkkynen, Jari Jokelainen, Kristiina Santalahti, Marko Salmi, Stefan Blankenberg, Tanja Zeller, Jorma Viikari, Mika Kähönen, Terho Lehtimäki, Veikko Salomaa, Markus Perola, Sirpa Jalkanen, Marjo Riitta Järvelin & 4 others Olli T. Raitakari, Johannes Kettunen, Debbie A. Lawlor, Mika Ala-Korpela

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

BACKGROUND: Pregnancy triggers well-known alterations in maternal glucose and lipid balance but its overall effects on systemic metabolism remain incompletely understood.

METHODS: Detailed molecular profiles (87 metabolic measures and 37 cytokines) were measured for up to 4260 women (24-49 years, 322 pregnant) from three population-based cohorts in Finland. Circulating molecular concentrations in pregnant women were compared to those in non-pregnant women. Metabolic profiles were also reassessed for 583 women 6 years later to uncover the longitudinal metabolic changes in response to change in the pregnancy status.

RESULTS: Compared to non-pregnant women, all lipoprotein subclasses and lipids were markedly increased in pregnant women. The most pronounced differences were observed for the intermediate-density, low-density and high-density lipoprotein triglyceride concentrations. Large differences were also seen for many fatty acids and amino acids. Pregnant women also had higher concentrations of low-grade inflammatory marker glycoprotein acetyls, higher concentrations of interleukin-18 and lower concentrations of interleukin-12p70. The changes in metabolic concentrations for women who were not pregnant at baseline but pregnant 6 years later (or vice versa) matched (or were mirror-images of) the cross-sectional association pattern. Cross-sectional results were consistent across the three cohorts and similar longitudinal changes were seen for 653 women in 4-year and 497 women in 10-year follow-up. For multiple metabolic measures, the changes increased in magnitude across the three trimesters.

CONCLUSIONS: Pregnancy initiates substantial metabolic and inflammatory changes in the mothers. Comprehensive characterisation of normal pregnancy is important for gaining understanding of the key nutrients for fetal growth and development. These findings also provide a valuable molecular reference in relation to studies of adverse pregnancy outcomes.

LanguageEnglish
Pages205
JournalBMC Medicine
Volume14
Issue number1
DOIs
Publication statusPublished - 13 Dec 2016

Keywords

  • Adult
  • Cross-Sectional Studies
  • Female
  • Finland
  • Humans
  • Metabolomics
  • Middle Aged
  • Pregnancy
  • Young Adult
  • Journal Article

Cite this

Wang, Q., Würtz, P., Auro, K., Makinen, V-P., Kangas, A. J., Soininen, P., ... Ala-Korpela, M. (2016). Metabolic profiling of pregnancy: cross-sectional and longitudinal evidence. BMC Medicine, 14(1), 205. https://doi.org/10.1186/s12916-016-0733-0
Wang, Qin ; Würtz, Peter ; Auro, Kirsi ; Makinen, Ville-Petteri ; Kangas, Antti J ; Soininen, Pasi ; Tiainen, Mika ; Tynkkynen, Tuulia ; Jokelainen, Jari ; Santalahti, Kristiina ; Salmi, Marko ; Blankenberg, Stefan ; Zeller, Tanja ; Viikari, Jorma ; Kähönen, Mika ; Lehtimäki, Terho ; Salomaa, Veikko ; Perola, Markus ; Jalkanen, Sirpa ; Järvelin, Marjo Riitta ; Raitakari, Olli T. ; Kettunen, Johannes ; Lawlor, Debbie A. ; Ala-Korpela, Mika. / Metabolic profiling of pregnancy : cross-sectional and longitudinal evidence. In: BMC Medicine. 2016 ; Vol. 14, No. 1. pp. 205.
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Wang, Q, Würtz, P, Auro, K, Makinen, V-P, Kangas, AJ, Soininen, P, Tiainen, M, Tynkkynen, T, Jokelainen, J, Santalahti, K, Salmi, M, Blankenberg, S, Zeller, T, Viikari, J, Kähönen, M, Lehtimäki, T, Salomaa, V, Perola, M, Jalkanen, S, Järvelin, MR, Raitakari, OT, Kettunen, J, Lawlor, DA & Ala-Korpela, M 2016, 'Metabolic profiling of pregnancy: cross-sectional and longitudinal evidence', BMC Medicine, vol. 14, no. 1, pp. 205. https://doi.org/10.1186/s12916-016-0733-0

Metabolic profiling of pregnancy : cross-sectional and longitudinal evidence. / Wang, Qin; Würtz, Peter; Auro, Kirsi; Makinen, Ville-Petteri; Kangas, Antti J; Soininen, Pasi; Tiainen, Mika; Tynkkynen, Tuulia; Jokelainen, Jari; Santalahti, Kristiina; Salmi, Marko; Blankenberg, Stefan; Zeller, Tanja; Viikari, Jorma; Kähönen, Mika; Lehtimäki, Terho; Salomaa, Veikko; Perola, Markus; Jalkanen, Sirpa; Järvelin, Marjo Riitta; Raitakari, Olli T.; Kettunen, Johannes; Lawlor, Debbie A.; Ala-Korpela, Mika.

In: BMC Medicine, Vol. 14, No. 1, 13.12.2016, p. 205.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Metabolic profiling of pregnancy

T2 - BMC Medicine

AU - Wang, Qin

AU - Würtz, Peter

AU - Auro, Kirsi

AU - Makinen, Ville-Petteri

AU - Kangas, Antti J

AU - Soininen, Pasi

AU - Tiainen, Mika

AU - Tynkkynen, Tuulia

AU - Jokelainen, Jari

AU - Santalahti, Kristiina

AU - Salmi, Marko

AU - Blankenberg, Stefan

AU - Zeller, Tanja

AU - Viikari, Jorma

AU - Kähönen, Mika

AU - Lehtimäki, Terho

AU - Salomaa, Veikko

AU - Perola, Markus

AU - Jalkanen, Sirpa

AU - Järvelin, Marjo Riitta

AU - Raitakari, Olli T.

AU - Kettunen, Johannes

AU - Lawlor, Debbie A.

AU - Ala-Korpela, Mika

PY - 2016/12/13

Y1 - 2016/12/13

N2 - BACKGROUND: Pregnancy triggers well-known alterations in maternal glucose and lipid balance but its overall effects on systemic metabolism remain incompletely understood.METHODS: Detailed molecular profiles (87 metabolic measures and 37 cytokines) were measured for up to 4260 women (24-49 years, 322 pregnant) from three population-based cohorts in Finland. Circulating molecular concentrations in pregnant women were compared to those in non-pregnant women. Metabolic profiles were also reassessed for 583 women 6 years later to uncover the longitudinal metabolic changes in response to change in the pregnancy status.RESULTS: Compared to non-pregnant women, all lipoprotein subclasses and lipids were markedly increased in pregnant women. The most pronounced differences were observed for the intermediate-density, low-density and high-density lipoprotein triglyceride concentrations. Large differences were also seen for many fatty acids and amino acids. Pregnant women also had higher concentrations of low-grade inflammatory marker glycoprotein acetyls, higher concentrations of interleukin-18 and lower concentrations of interleukin-12p70. The changes in metabolic concentrations for women who were not pregnant at baseline but pregnant 6 years later (or vice versa) matched (or were mirror-images of) the cross-sectional association pattern. Cross-sectional results were consistent across the three cohorts and similar longitudinal changes were seen for 653 women in 4-year and 497 women in 10-year follow-up. For multiple metabolic measures, the changes increased in magnitude across the three trimesters.CONCLUSIONS: Pregnancy initiates substantial metabolic and inflammatory changes in the mothers. Comprehensive characterisation of normal pregnancy is important for gaining understanding of the key nutrients for fetal growth and development. These findings also provide a valuable molecular reference in relation to studies of adverse pregnancy outcomes.

AB - BACKGROUND: Pregnancy triggers well-known alterations in maternal glucose and lipid balance but its overall effects on systemic metabolism remain incompletely understood.METHODS: Detailed molecular profiles (87 metabolic measures and 37 cytokines) were measured for up to 4260 women (24-49 years, 322 pregnant) from three population-based cohorts in Finland. Circulating molecular concentrations in pregnant women were compared to those in non-pregnant women. Metabolic profiles were also reassessed for 583 women 6 years later to uncover the longitudinal metabolic changes in response to change in the pregnancy status.RESULTS: Compared to non-pregnant women, all lipoprotein subclasses and lipids were markedly increased in pregnant women. The most pronounced differences were observed for the intermediate-density, low-density and high-density lipoprotein triglyceride concentrations. Large differences were also seen for many fatty acids and amino acids. Pregnant women also had higher concentrations of low-grade inflammatory marker glycoprotein acetyls, higher concentrations of interleukin-18 and lower concentrations of interleukin-12p70. The changes in metabolic concentrations for women who were not pregnant at baseline but pregnant 6 years later (or vice versa) matched (or were mirror-images of) the cross-sectional association pattern. Cross-sectional results were consistent across the three cohorts and similar longitudinal changes were seen for 653 women in 4-year and 497 women in 10-year follow-up. For multiple metabolic measures, the changes increased in magnitude across the three trimesters.CONCLUSIONS: Pregnancy initiates substantial metabolic and inflammatory changes in the mothers. Comprehensive characterisation of normal pregnancy is important for gaining understanding of the key nutrients for fetal growth and development. These findings also provide a valuable molecular reference in relation to studies of adverse pregnancy outcomes.

KW - Adult

KW - Cross-Sectional Studies

KW - Female

KW - Finland

KW - Humans

KW - Metabolomics

KW - Middle Aged

KW - Pregnancy

KW - Young Adult

KW - Journal Article

U2 - 10.1186/s12916-016-0733-0

DO - 10.1186/s12916-016-0733-0

M3 - Article

VL - 14

SP - 205

JO - BMC Medicine

JF - BMC Medicine

SN - 1741-7015

IS - 1

ER -