Metabolic, immunological and clinical characteristics in newly diagnosed Asian diabetes patients aged 12-40 years

C. Y. Pan, W. Y. So, B. A.K. Khalid, V. Mohan, A. C. Thai, Paul Zimmet, C. S. Cockram, L. N. Jorgensen, J. P. Yeo

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Aim: To describe the clinical, biochemical and immunological characteristics of young-onset diabetes in Asia. Methods: Clinical, biochemical and immunological variables were assessed in 919 newly diagnosed (duration less than 12 months) young onset Asian diabetic patients aged between 12 and 40 years. The subjects constituted 57% Chinese, 29% Indians and 14% Malays, recruited from diabetes centres in China, Hong Kong, India, Malaysia and Singapore. Results: The mean age (± SD) was 31.6 ± 7.2 years, with the majority (66%) in the 31-40 years age group. Mean body mass index (BMI) (± SD) was 25.3 ± 5.0 kg/m2 with 47% exceeding the suggested Asian cut-off point for obesity (BMI > 25). Ethnic difference in clinical characteristics included BMI, blood pressure, mode of treatment and degree of insulin resistance. Most patients had a clinical presentation of Type 2 diabetes. About 10% had a classical combination of ketotic presentation, presence of autoimmune-markers and documented insulin deficiency indicative of Type 1 diabetes. Forty-eight percent were receiving oral hypoglycaemic agents (OHAs) while 31% were on diet only, 18% were receiving insulin and 2% were on a combination of insulin and OHA. Conclusion: Young onset diabetes patients in Asia represent a heterogenous group in terms of their clinical and biochemical characteristics and classical Type 1 diabetes is relatively uncommon. The 5-year follow up study will determine the progress of these patients and help to clarify the natural history.

LanguageEnglish
Pages1007-1013
Number of pages7
JournalDiabetic Medicine
Volume21
Issue number9
DOIs
Publication statusPublished - 1 Sep 2004

Keywords

  • Asians
  • Autoantibodies
  • C-peptide
  • Diabetes mellitus
  • Insulin deficient

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Pan, C. Y., So, W. Y., Khalid, B. A. K., Mohan, V., Thai, A. C., Zimmet, P., ... Yeo, J. P. (2004). Metabolic, immunological and clinical characteristics in newly diagnosed Asian diabetes patients aged 12-40 years. Diabetic Medicine, 21(9), 1007-1013. https://doi.org/10.1111/j.1464-5491.2004.01287.x
Pan, C. Y. ; So, W. Y. ; Khalid, B. A.K. ; Mohan, V. ; Thai, A. C. ; Zimmet, Paul ; Cockram, C. S. ; Jorgensen, L. N. ; Yeo, J. P. / Metabolic, immunological and clinical characteristics in newly diagnosed Asian diabetes patients aged 12-40 years. In: Diabetic Medicine. 2004 ; Vol. 21, No. 9. pp. 1007-1013.
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Pan, CY, So, WY, Khalid, BAK, Mohan, V, Thai, AC, Zimmet, P, Cockram, CS, Jorgensen, LN & Yeo, JP 2004, 'Metabolic, immunological and clinical characteristics in newly diagnosed Asian diabetes patients aged 12-40 years', Diabetic Medicine, vol. 21, no. 9, pp. 1007-1013. https://doi.org/10.1111/j.1464-5491.2004.01287.x

Metabolic, immunological and clinical characteristics in newly diagnosed Asian diabetes patients aged 12-40 years. / Pan, C. Y.; So, W. Y.; Khalid, B. A.K.; Mohan, V.; Thai, A. C.; Zimmet, Paul; Cockram, C. S.; Jorgensen, L. N.; Yeo, J. P.

In: Diabetic Medicine, Vol. 21, No. 9, 01.09.2004, p. 1007-1013.

Research output: Contribution to journalArticle

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T1 - Metabolic, immunological and clinical characteristics in newly diagnosed Asian diabetes patients aged 12-40 years

AU - Pan, C. Y.

AU - So, W. Y.

AU - Khalid, B. A.K.

AU - Mohan, V.

AU - Thai, A. C.

AU - Zimmet, Paul

AU - Cockram, C. S.

AU - Jorgensen, L. N.

AU - Yeo, J. P.

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N2 - Aim: To describe the clinical, biochemical and immunological characteristics of young-onset diabetes in Asia. Methods: Clinical, biochemical and immunological variables were assessed in 919 newly diagnosed (duration less than 12 months) young onset Asian diabetic patients aged between 12 and 40 years. The subjects constituted 57% Chinese, 29% Indians and 14% Malays, recruited from diabetes centres in China, Hong Kong, India, Malaysia and Singapore. Results: The mean age (± SD) was 31.6 ± 7.2 years, with the majority (66%) in the 31-40 years age group. Mean body mass index (BMI) (± SD) was 25.3 ± 5.0 kg/m2 with 47% exceeding the suggested Asian cut-off point for obesity (BMI > 25). Ethnic difference in clinical characteristics included BMI, blood pressure, mode of treatment and degree of insulin resistance. Most patients had a clinical presentation of Type 2 diabetes. About 10% had a classical combination of ketotic presentation, presence of autoimmune-markers and documented insulin deficiency indicative of Type 1 diabetes. Forty-eight percent were receiving oral hypoglycaemic agents (OHAs) while 31% were on diet only, 18% were receiving insulin and 2% were on a combination of insulin and OHA. Conclusion: Young onset diabetes patients in Asia represent a heterogenous group in terms of their clinical and biochemical characteristics and classical Type 1 diabetes is relatively uncommon. The 5-year follow up study will determine the progress of these patients and help to clarify the natural history.

AB - Aim: To describe the clinical, biochemical and immunological characteristics of young-onset diabetes in Asia. Methods: Clinical, biochemical and immunological variables were assessed in 919 newly diagnosed (duration less than 12 months) young onset Asian diabetic patients aged between 12 and 40 years. The subjects constituted 57% Chinese, 29% Indians and 14% Malays, recruited from diabetes centres in China, Hong Kong, India, Malaysia and Singapore. Results: The mean age (± SD) was 31.6 ± 7.2 years, with the majority (66%) in the 31-40 years age group. Mean body mass index (BMI) (± SD) was 25.3 ± 5.0 kg/m2 with 47% exceeding the suggested Asian cut-off point for obesity (BMI > 25). Ethnic difference in clinical characteristics included BMI, blood pressure, mode of treatment and degree of insulin resistance. Most patients had a clinical presentation of Type 2 diabetes. About 10% had a classical combination of ketotic presentation, presence of autoimmune-markers and documented insulin deficiency indicative of Type 1 diabetes. Forty-eight percent were receiving oral hypoglycaemic agents (OHAs) while 31% were on diet only, 18% were receiving insulin and 2% were on a combination of insulin and OHA. Conclusion: Young onset diabetes patients in Asia represent a heterogenous group in terms of their clinical and biochemical characteristics and classical Type 1 diabetes is relatively uncommon. The 5-year follow up study will determine the progress of these patients and help to clarify the natural history.

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KW - Autoantibodies

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