Metabolic, immunological and clinical characteristics in newly diagnosed Asian diabetes patients aged 12-40 years

C. Y. Pan, W. Y. So, B. A.K. Khalid, V. Mohan, A. C. Thai, Paul Zimmet, C. S. Cockram, L. N. Jorgensen, J. P. Yeo

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23 Citations (Scopus)

Abstract

Aim: To describe the clinical, biochemical and immunological characteristics of young-onset diabetes in Asia. Methods: Clinical, biochemical and immunological variables were assessed in 919 newly diagnosed (duration less than 12 months) young onset Asian diabetic patients aged between 12 and 40 years. The subjects constituted 57% Chinese, 29% Indians and 14% Malays, recruited from diabetes centres in China, Hong Kong, India, Malaysia and Singapore. Results: The mean age (± SD) was 31.6 ± 7.2 years, with the majority (66%) in the 31-40 years age group. Mean body mass index (BMI) (± SD) was 25.3 ± 5.0 kg/m2 with 47% exceeding the suggested Asian cut-off point for obesity (BMI > 25). Ethnic difference in clinical characteristics included BMI, blood pressure, mode of treatment and degree of insulin resistance. Most patients had a clinical presentation of Type 2 diabetes. About 10% had a classical combination of ketotic presentation, presence of autoimmune-markers and documented insulin deficiency indicative of Type 1 diabetes. Forty-eight percent were receiving oral hypoglycaemic agents (OHAs) while 31% were on diet only, 18% were receiving insulin and 2% were on a combination of insulin and OHA. Conclusion: Young onset diabetes patients in Asia represent a heterogenous group in terms of their clinical and biochemical characteristics and classical Type 1 diabetes is relatively uncommon. The 5-year follow up study will determine the progress of these patients and help to clarify the natural history.

Original languageEnglish
Pages (from-to)1007-1013
Number of pages7
JournalDiabetic Medicine
Volume21
Issue number9
DOIs
Publication statusPublished - 1 Sep 2004

Keywords

  • Asians
  • Autoantibodies
  • C-peptide
  • Diabetes mellitus
  • Insulin deficient

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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