Mesenchymal stem cell-mediated functional tooth regeneration in Swine

Wataru Sonoyama, Yi Liu, Dianji Fang, Takayoshi Yamaza, Byoung Moo Seo, Chunmei Zhang, He Liu, Stan Gronthos, Cun Yu Wang, Songtao Shi, Songlin Wang

Research output: Contribution to journalArticle

672 Citations (Scopus)

Abstract

Mesenchymal stem cell-mediated tissue regeneration is a promising approach for regenerative medicine for a wide range of applications. Here we report a new population of stem cells isolated from the root apical papilla of human teeth (SCAP, stem cells from apical papilla). Using a minipig model, we transplanted both human SCAP and periodontal ligament stem cells (PDLSCs) to generate a root/periodontal complex capable of supporting a porcelain crown, resulting in normal tooth function. This work integrates a stem cell-mediated tissue regeneration strategy, engineered materials for structure, and current dental crown technologies. This hybridized tissue engineering approach led to recovery of tooth strength and appearance.

LanguageEnglish
Article numbere79
JournalPloS one
Volume1
Issue number1
DOIs
Publication statusPublished - 20 Dec 2006

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Sonoyama, W., Liu, Y., Fang, D., Yamaza, T., Seo, B. M., Zhang, C., ... Wang, S. (2006). Mesenchymal stem cell-mediated functional tooth regeneration in Swine. PloS one, 1(1), [e79]. https://doi.org/10.1371/journal.pone.0000079
Sonoyama, Wataru ; Liu, Yi ; Fang, Dianji ; Yamaza, Takayoshi ; Seo, Byoung Moo ; Zhang, Chunmei ; Liu, He ; Gronthos, Stan ; Wang, Cun Yu ; Shi, Songtao ; Wang, Songlin. / Mesenchymal stem cell-mediated functional tooth regeneration in Swine. In: PloS one. 2006 ; Vol. 1, No. 1.
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Sonoyama, W, Liu, Y, Fang, D, Yamaza, T, Seo, BM, Zhang, C, Liu, H, Gronthos, S, Wang, CY, Shi, S & Wang, S 2006, 'Mesenchymal stem cell-mediated functional tooth regeneration in Swine', PloS one, vol. 1, no. 1, e79. https://doi.org/10.1371/journal.pone.0000079

Mesenchymal stem cell-mediated functional tooth regeneration in Swine. / Sonoyama, Wataru; Liu, Yi; Fang, Dianji; Yamaza, Takayoshi; Seo, Byoung Moo; Zhang, Chunmei; Liu, He; Gronthos, Stan; Wang, Cun Yu; Shi, Songtao; Wang, Songlin.

In: PloS one, Vol. 1, No. 1, e79, 20.12.2006.

Research output: Contribution to journalArticle

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AU - Sonoyama, Wataru

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AU - Zhang, Chunmei

AU - Liu, He

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AU - Shi, Songtao

AU - Wang, Songlin

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Sonoyama W, Liu Y, Fang D, Yamaza T, Seo BM, Zhang C et al. Mesenchymal stem cell-mediated functional tooth regeneration in Swine. PloS one. 2006 Dec 20;1(1). e79. https://doi.org/10.1371/journal.pone.0000079