Mesenchymal lineage precursor cells induce vascular network formation in ischemic myocardium

Timothy P. Martens, Fiona See, Michael D. Schuster, Hugo P. Sondermeijer, Marco M. Hefti, Andrew Zannettino, Stan Gronthos, Tetsunori Seki, Silviu Itescu

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

Mesenchymal lineage precursors can be reproducibly isolated from adult mammalian bone marrow and grown in culture. Immunoselection with monoclonal antibodies against STRO-1 and vascular-cell-adhesion molecule 1 (VCAM1/CD106) prior to expansion results in a 1,000-fold enrichment of mesenchymal precursors compared to standard isolation techniques. Intramyocardial injection of human STRO-1-selected precursors in an athymic rat model of acute myocardial infarction results in induction of vascular network formation and arteriogenesis coupled with global functional cardiac recovery.

Original languageEnglish
JournalNature Clinical Practice Cardiovascular Medicine
Volume3
Issue numberSUPPL. 1
DOIs
Publication statusPublished - 1 Mar 2006
Externally publishedYes

Keywords

  • Cardiac myogenesis
  • Cardiac neovascularization
  • Mesenchymal precursor cells
  • STRO-1
  • VCAM1

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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