Mechanisms of corneal allograft rejection and regional immunosuppression

D. J. Coster, C. F. Jessup, K. A. Williams

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Corneal transplantation has not matched the improvements in outcome seen with other clinical transplantation procedures. The therapeutic strategies, which have improved the outcomes of solid vascularised organs are not applicable to corneal transplantation. Corneal transplantation is different with respect to relevant transplantation biology and the clinical context in which it is practiced. New approaches need to be developed which provide regional rather than systemic immunosuppression. The accessibility of the cornea makes it particularly suitable for topical medication and for gene therapy approaches. Engineered antibodies, small enough to pass through the cornea, and directed at key molecules in the allograft response have been developed. Gene therapy had been developed using viral vectors to transfect the corneal endothelium with the genes for immunosuppressive lymphokines. Both approaches show promise.

Original languageEnglish
Pages (from-to)1894-1897
Number of pages4
JournalEye
Volume23
Issue number10
DOIs
Publication statusPublished or Issued - Oct 2009
Externally publishedYes

Keywords

  • Allograft rejection
  • Corneal transplantation
  • Gene therapy
  • Modified antibodies

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

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