Meal-sensing signaling pathways in functional dyspepsia

Research output: Contribution to journalShort surveypeer-review

3 Citations (Scopus)

Abstract

The upper gastrointestinal tract plays an important role in sensing the arrival, amount and chemical composition of a meal. Ingestion of a meal triggers a number of sensory signals in the gastrointestinal tract. These include the response to mechanical stimulation (e.g., gastric distension), from the presence of food in the gut, and the interaction of various dietary nutrients with specific “taste” receptors on specialized enteroendocrine cells in the small intestine culminating in the release of gut hormones. These signals are then transmitted to the brain where they contribute to food intake regulation by modulating appetite as well as feedback control of gastrointestinal functions (e.g., gut motility). There is evidence that the sensitivity to these food related stimuli is abnormally enhanced in functional dyspepsia leading to symptoms such nausea and bloating. In addition, these gut-brain signals can modulate the signaling pathways involved in visceral pain. This review will discuss the role of gut-brain signals in appetite regulation and the role dysregulation of this system play in functional dyspepsia.

Original languageEnglish
Article number10
JournalFrontiers in Systems Neuroscience
Volume12
DOIs
Publication statusPublished or Issued - 5 Apr 2018

Keywords

  • Chemosensation
  • Functional dyspepsia
  • Gastrointestinal tract
  • Mechanosensation
  • Pain
  • Vagal afferents

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Developmental Neuroscience
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

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