Maternal body mass index, excess gestational weight gain, and diabetes are positively associated with neonatal adiposity in the Pregnancy and Neonatal Diabetes Outcomes in Remote Australia (PANDORA) study

Danielle K. Longmore, Elizabeth L.M. Barr, I. Lynn Lee, Federica Barzi, Marie Kirkwood, Cherie Whitbread, Vanya Hampton, Sian Graham, Paula Van Dokkum, Christine Connors, Jacqueline A. Boyle, Patrick Catalano, Alex D.H. Brown, Kerin O'Dea, Jeremy Oats, H. David McIntyre, Jonathan E. Shaw, Louise J. Maple-Brown, on behalf of the PANDORA study research team

Research output: Research - peer-reviewArticle

Abstract

Background: In-utero exposures likely influence the onset and severity of obesity in youth. With increasing rates of type 2 diabetes mellitus (T2DM) and maternal adiposity in pregnancy globally, it is important to assess the impact of these factors on neonatal adipose measures. Objectives: To evaluate the contribution of maternal ethnicity, body mass index (BMI), gestational weight gain, and hyperglycaemia to neonatal adiposity. Methods: Pregnancy and Neonatal Diabetes Outcomes in Remote Australia (PANDORA) is a longitudinal cohort study of Australian mother and neonate pairs. In this analysis, Indigenous (n = 519) and Europid (n = 358) women were included, of whom 644 had hyperglycaemia (type 2 diabetes [T2DM], diabetes in pregnancy [DIP], or gestational diabetes [GDM]). Associations between maternal ethnicity, hyperglycaemia, BMI and gestational weight gain, and the neonatal outcomes of length, head circumference, sum of skinfolds, total body fat, and percentage body fat were examined. Models were adjusted for maternal age, smoking status, parity, education, neonatal gender, and gestational age. Results: Among those with hyperglycaemia in pregnancy, Indigenous women had a higher proportion of T2DM and DIP (36%, 13%) compared with Europid women (4%, 3%). In multivariate analysis, maternal T2DM (compared with no hyperglycaemia), BMI during pregnancy, and excess compared with appropriate gestational weight gain, were significantly associated with greater neonatal measures. DIP was associated with greater sum of skinfolds, total body fat, and percentage body fat. Indigenous ethnicity was associated with greater sum of skinfolds. Conclusions: Maternal BMI, excess gestational weight gain, and hyperglycaemia operated as independent factors influencing neonatal adiposity. Interventions addressing these factors are needed to reduce neonatal adiposity.

LanguageEnglish
Article numbere12490
JournalPediatric Obesity
DOIs
StateAccepted/In press - 2019

Keywords

  • adiposity
  • diabetes
  • indigenous
  • neonatal

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Health Policy
  • Nutrition and Dietetics
  • Public Health, Environmental and Occupational Health

Cite this

Longmore, D. K., Barr, E. L. M., Lee, I. L., Barzi, F., Kirkwood, M., Whitbread, C., ... on behalf of the PANDORA study research team (2019). Maternal body mass index, excess gestational weight gain, and diabetes are positively associated with neonatal adiposity in the Pregnancy and Neonatal Diabetes Outcomes in Remote Australia (PANDORA) study. Pediatric Obesity, [e12490]. DOI: 10.1111/ijpo.12490
Longmore, Danielle K. ; Barr, Elizabeth L.M. ; Lee, I. Lynn ; Barzi, Federica ; Kirkwood, Marie ; Whitbread, Cherie ; Hampton, Vanya ; Graham, Sian ; Van Dokkum, Paula ; Connors, Christine ; Boyle, Jacqueline A. ; Catalano, Patrick ; Brown, Alex D.H. ; O'Dea, Kerin ; Oats, Jeremy ; McIntyre, H. David ; Shaw, Jonathan E. ; Maple-Brown, Louise J. ; on behalf of the PANDORA study research team. / Maternal body mass index, excess gestational weight gain, and diabetes are positively associated with neonatal adiposity in the Pregnancy and Neonatal Diabetes Outcomes in Remote Australia (PANDORA) study. In: Pediatric Obesity. 2019
@article{4ae85a5ffa5b4e55bb6cf6742d38dfc1,
title = "Maternal body mass index, excess gestational weight gain, and diabetes are positively associated with neonatal adiposity in the Pregnancy and Neonatal Diabetes Outcomes in Remote Australia (PANDORA) study",
abstract = "Background: In-utero exposures likely influence the onset and severity of obesity in youth. With increasing rates of type 2 diabetes mellitus (T2DM) and maternal adiposity in pregnancy globally, it is important to assess the impact of these factors on neonatal adipose measures. Objectives: To evaluate the contribution of maternal ethnicity, body mass index (BMI), gestational weight gain, and hyperglycaemia to neonatal adiposity. Methods: Pregnancy and Neonatal Diabetes Outcomes in Remote Australia (PANDORA) is a longitudinal cohort study of Australian mother and neonate pairs. In this analysis, Indigenous (n = 519) and Europid (n = 358) women were included, of whom 644 had hyperglycaemia (type 2 diabetes [T2DM], diabetes in pregnancy [DIP], or gestational diabetes [GDM]). Associations between maternal ethnicity, hyperglycaemia, BMI and gestational weight gain, and the neonatal outcomes of length, head circumference, sum of skinfolds, total body fat, and percentage body fat were examined. Models were adjusted for maternal age, smoking status, parity, education, neonatal gender, and gestational age. Results: Among those with hyperglycaemia in pregnancy, Indigenous women had a higher proportion of T2DM and DIP (36%, 13%) compared with Europid women (4%, 3%). In multivariate analysis, maternal T2DM (compared with no hyperglycaemia), BMI during pregnancy, and excess compared with appropriate gestational weight gain, were significantly associated with greater neonatal measures. DIP was associated with greater sum of skinfolds, total body fat, and percentage body fat. Indigenous ethnicity was associated with greater sum of skinfolds. Conclusions: Maternal BMI, excess gestational weight gain, and hyperglycaemia operated as independent factors influencing neonatal adiposity. Interventions addressing these factors are needed to reduce neonatal adiposity.",
keywords = "adiposity, diabetes, indigenous, neonatal",
author = "Longmore, {Danielle K.} and Barr, {Elizabeth L.M.} and Lee, {I. Lynn} and Federica Barzi and Marie Kirkwood and Cherie Whitbread and Vanya Hampton and Sian Graham and {Van Dokkum}, Paula and Christine Connors and Boyle, {Jacqueline A.} and Patrick Catalano and Brown, {Alex D.H.} and Kerin O'Dea and Jeremy Oats and McIntyre, {H. David} and Shaw, {Jonathan E.} and Maple-Brown, {Louise J.} and {on behalf of the PANDORA study research team}",
year = "2019",
doi = "10.1111/ijpo.12490",
journal = "Pediatric Obesity",
issn = "2047-6302",
publisher = "Wiley-Blackwell for the International Association for the Study of Obesity",

}

Longmore, DK, Barr, ELM, Lee, IL, Barzi, F, Kirkwood, M, Whitbread, C, Hampton, V, Graham, S, Van Dokkum, P, Connors, C, Boyle, JA, Catalano, P, Brown, ADH, O'Dea, K, Oats, J, McIntyre, HD, Shaw, JE, Maple-Brown, LJ & on behalf of the PANDORA study research team 2019, 'Maternal body mass index, excess gestational weight gain, and diabetes are positively associated with neonatal adiposity in the Pregnancy and Neonatal Diabetes Outcomes in Remote Australia (PANDORA) study' Pediatric Obesity. DOI: 10.1111/ijpo.12490

Maternal body mass index, excess gestational weight gain, and diabetes are positively associated with neonatal adiposity in the Pregnancy and Neonatal Diabetes Outcomes in Remote Australia (PANDORA) study. / Longmore, Danielle K.; Barr, Elizabeth L.M.; Lee, I. Lynn; Barzi, Federica; Kirkwood, Marie; Whitbread, Cherie; Hampton, Vanya; Graham, Sian; Van Dokkum, Paula; Connors, Christine; Boyle, Jacqueline A.; Catalano, Patrick; Brown, Alex D.H.; O'Dea, Kerin; Oats, Jeremy; McIntyre, H. David; Shaw, Jonathan E.; Maple-Brown, Louise J.; on behalf of the PANDORA study research team.

In: Pediatric Obesity, 2019.

Research output: Research - peer-reviewArticle

TY - JOUR

T1 - Maternal body mass index, excess gestational weight gain, and diabetes are positively associated with neonatal adiposity in the Pregnancy and Neonatal Diabetes Outcomes in Remote Australia (PANDORA) study

AU - Longmore,Danielle K.

AU - Barr,Elizabeth L.M.

AU - Lee,I. Lynn

AU - Barzi,Federica

AU - Kirkwood,Marie

AU - Whitbread,Cherie

AU - Hampton,Vanya

AU - Graham,Sian

AU - Van Dokkum,Paula

AU - Connors,Christine

AU - Boyle,Jacqueline A.

AU - Catalano,Patrick

AU - Brown,Alex D.H.

AU - O'Dea,Kerin

AU - Oats,Jeremy

AU - McIntyre,H. David

AU - Shaw,Jonathan E.

AU - Maple-Brown,Louise J.

AU - on behalf of the PANDORA study research team

PY - 2019

Y1 - 2019

N2 - Background: In-utero exposures likely influence the onset and severity of obesity in youth. With increasing rates of type 2 diabetes mellitus (T2DM) and maternal adiposity in pregnancy globally, it is important to assess the impact of these factors on neonatal adipose measures. Objectives: To evaluate the contribution of maternal ethnicity, body mass index (BMI), gestational weight gain, and hyperglycaemia to neonatal adiposity. Methods: Pregnancy and Neonatal Diabetes Outcomes in Remote Australia (PANDORA) is a longitudinal cohort study of Australian mother and neonate pairs. In this analysis, Indigenous (n = 519) and Europid (n = 358) women were included, of whom 644 had hyperglycaemia (type 2 diabetes [T2DM], diabetes in pregnancy [DIP], or gestational diabetes [GDM]). Associations between maternal ethnicity, hyperglycaemia, BMI and gestational weight gain, and the neonatal outcomes of length, head circumference, sum of skinfolds, total body fat, and percentage body fat were examined. Models were adjusted for maternal age, smoking status, parity, education, neonatal gender, and gestational age. Results: Among those with hyperglycaemia in pregnancy, Indigenous women had a higher proportion of T2DM and DIP (36%, 13%) compared with Europid women (4%, 3%). In multivariate analysis, maternal T2DM (compared with no hyperglycaemia), BMI during pregnancy, and excess compared with appropriate gestational weight gain, were significantly associated with greater neonatal measures. DIP was associated with greater sum of skinfolds, total body fat, and percentage body fat. Indigenous ethnicity was associated with greater sum of skinfolds. Conclusions: Maternal BMI, excess gestational weight gain, and hyperglycaemia operated as independent factors influencing neonatal adiposity. Interventions addressing these factors are needed to reduce neonatal adiposity.

AB - Background: In-utero exposures likely influence the onset and severity of obesity in youth. With increasing rates of type 2 diabetes mellitus (T2DM) and maternal adiposity in pregnancy globally, it is important to assess the impact of these factors on neonatal adipose measures. Objectives: To evaluate the contribution of maternal ethnicity, body mass index (BMI), gestational weight gain, and hyperglycaemia to neonatal adiposity. Methods: Pregnancy and Neonatal Diabetes Outcomes in Remote Australia (PANDORA) is a longitudinal cohort study of Australian mother and neonate pairs. In this analysis, Indigenous (n = 519) and Europid (n = 358) women were included, of whom 644 had hyperglycaemia (type 2 diabetes [T2DM], diabetes in pregnancy [DIP], or gestational diabetes [GDM]). Associations between maternal ethnicity, hyperglycaemia, BMI and gestational weight gain, and the neonatal outcomes of length, head circumference, sum of skinfolds, total body fat, and percentage body fat were examined. Models were adjusted for maternal age, smoking status, parity, education, neonatal gender, and gestational age. Results: Among those with hyperglycaemia in pregnancy, Indigenous women had a higher proportion of T2DM and DIP (36%, 13%) compared with Europid women (4%, 3%). In multivariate analysis, maternal T2DM (compared with no hyperglycaemia), BMI during pregnancy, and excess compared with appropriate gestational weight gain, were significantly associated with greater neonatal measures. DIP was associated with greater sum of skinfolds, total body fat, and percentage body fat. Indigenous ethnicity was associated with greater sum of skinfolds. Conclusions: Maternal BMI, excess gestational weight gain, and hyperglycaemia operated as independent factors influencing neonatal adiposity. Interventions addressing these factors are needed to reduce neonatal adiposity.

KW - adiposity

KW - diabetes

KW - indigenous

KW - neonatal

UR - http://www.scopus.com/inward/record.url?scp=85060154860&partnerID=8YFLogxK

U2 - 10.1111/ijpo.12490

DO - 10.1111/ijpo.12490

M3 - Article

JO - Pediatric Obesity

T2 - Pediatric Obesity

JF - Pediatric Obesity

SN - 2047-6302

M1 - e12490

ER -