Matched unrelated donor bone marrow transplantation for chronic myeloid leukaemia in chronic phase: Comparison of ex vivo and in vivo T-cell depletion

J. O. Cullis, R. M. Szydlo, N. C.P. Cross, D. I. Marks, A. P. Schwarer, Timothy Hughes, S. MacKinnon, G. Hale, H. Waldmann, J. M. Hows, A. J. Barrett, J. M. Goldman

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12 Citations (Scopus)

Abstract

Between January 1985 and March 1992, 48 patients with chronic phase CML underwent BMT from volunteer unrelated donors (MUD) serologically identical at HLA-A, B and DR loci. 19 patients received donor marrow ex vivo T-cell depleted (EX-TCD) with Campath monoclonal antibodies. 29 patients received unmanipulated donor marrow with CsA/MTX GVHD prophylaxis; 28 received additional intravenous antilymphocyte therapy from day +1 to +5 (IN-TCD). Overall 26 patients survive at median follow up of 362 days; actuarial survival at 3 years is 50%. 3 patients have sustained haematological relapse; actuarial leukaemia-free survival is 38%. There is no difference in overall survival between the EX-TCD and IN-TCD groups, but primary graft failure (n = 4 ) occurred only in the EX-TCD group, while GVHD (grade II or greater) occurred more frequently in the IN-TCD group (61% vs. 29%, p = 0.084). The optimum method for GVHD prophylaxis in MUD BMT remains uncertain.

LanguageEnglish
Pages107-111
Number of pages5
JournalBone Marrow Transplantation
Volume11
Issue numberSUPPL. 1
Publication statusPublished - 30 Mar 1993
Externally publishedYes

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

Cullis, J. O., Szydlo, R. M., Cross, N. C. P., Marks, D. I., Schwarer, A. P., Hughes, T., ... Goldman, J. M. (1993). Matched unrelated donor bone marrow transplantation for chronic myeloid leukaemia in chronic phase: Comparison of ex vivo and in vivo T-cell depletion. Bone Marrow Transplantation, 11(SUPPL. 1), 107-111.