Lymphoproliferative disease after renal transplantation in Australia and New Zealand

Randall J. Faull, Peter Hollett, Stephen McDonald

Research output: Contribution to journalReview article

92 Citations (Scopus)

Abstract

Background. Lymphoproliferative disease is a common and serious complication of organ transplantation. It is well documented that the risk of its development increases with the level of immunosuppression. Less is known about its incidence, prevalence, timing, and prognosis. Methods. The authors conducted a retrospective review of all patients with lymphoproliferative disease after renal transplantation documented in the Australia and New Zealand Dialysis and Transplant Registry from 1970 to March 2003. Results. One hundred ninety-seven cases of lymphoproliferative disease occurred in 15,930 allografts in 13,516 recipients. There has been a steady increase in its incidence and prevalence each decade since 1970. Cases cluster into an early group (<2 years after transplantation) and a late group (5-10 years after transplantation). Risk factors include exposure to a calcineurin inhibitor, but there was no increased risk in those treated with anti-T-lymphocyte antibodies. Patient survival was poor: 51% at 1 year and 39% at 5 years. Conclusions. Lymphoproliferative disease is an increasingly common problem after renal transplantation, and the outcome is poor. Measures to reduce its incidence might include reduction of long-term immunosuppression exposure. Established disease has a high short-term mortality, and new treatment options, such as anti-B-lymphocyte monoclonal antibodies, should be aggressively pursued.

LanguageEnglish
Pages193-197
Number of pages5
JournalTransplantation
Volume80
Issue number2
DOIs
Publication statusPublished - 27 Jul 2005
Externally publishedYes

Keywords

  • Australia and New Zealand Dialysis and Transplant Registry Registry
  • Cancer
  • Lymphoma
  • Posttransplant lymphoproliferative disorder
  • Renal transplantation

ASJC Scopus subject areas

  • Transplantation

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