Long-term outcomes of left bundle branch block in high-risk survivors of acute myocardial infarction: The VALIANT experience

Kent Stephenson, Hicham Skali, John J V McMurray, Eric J. Velazquez, Philip G. Aylward, Lars Kober, Frans Van de Werf, Harvey D. White, Karen S. Pieper, Robert M. Califf, Scott D. Solomon, Marc A. Pfeffer

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23 Citations (Scopus)

Abstract

Background: In survivors of myocardial infarction (MI), new left bundle branch block (LBBB) is associated with adverse outcomes, but its impact is not well described in post-MI patients with left ventricular (LV) systolic dysfunction and/or heart failure (HF). Objectives: The aim of this study was to determine if new LBBB is an independent predictor of long-term fatal and nonfatal outcomes in high-risk survivors of MI by reviewing data from the VALsartan In Acute myocardial iNfarcTion (VALIANT) trial. Methods: In VALIANT, 14,703 patients with LV systolic dysfunction and/or HF were randomized to valsartan, captopril, or both a mean of 5 days after MI. Baseline ECG data were available from 14,259 patients. We assessed the predictive value of new LBBB for death and major cardiovascular outcomes after 3 years, adjusting for multiple baseline covariates including LV ejection fraction. Results: At follow-up, patients with new LBBB (608 [4.2%]) compared with patients without new LBBB had more comorbidities and increased adjusted risk of death (hazard ratio [HR] 1.3, 95% confidence interval [CI] 1.2-1.6), cardiovascular death (HR 1.4, 95% CI 1.2-1.7), HF (HR 1.3, 95% CI 1.1-1.6), MI (HR 1.5, 95% CI 1.2-1.9), and the composite of death, HF, or MI (HR 1.4, 95% CI 1.2-1.6). Conclusion: In post-MI survivors with LV systolic dysfunction and/or HF, new LBBB was an independent predictor of all major adverse cardiovascular outcomes during long-term follow-up. This readily available ECG marker should be considered a major risk factor for long-term cardiovascular complications in high-risk patients after MI.

Original languageEnglish
Pages (from-to)308-313
Number of pages6
JournalHeart Rhythm
Volume4
Issue number3
DOIs
Publication statusPublished - 1 Mar 2007

Keywords

  • Heart failure
  • Left bundle branch block
  • Left ventricular systolic dysfunction
  • Mortality
  • Myocardial infarction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Stephenson, K., Skali, H., McMurray, J. J. V., Velazquez, E. J., Aylward, P. G., Kober, L., ... Pfeffer, M. A. (2007). Long-term outcomes of left bundle branch block in high-risk survivors of acute myocardial infarction: The VALIANT experience. Heart Rhythm, 4(3), 308-313. https://doi.org/10.1016/j.hrthm.2006.11.021