Long QT Syndrome Type 1 in an Australian Indigenous Patient

Anand N. Ganesan, Carlos G. Vanoye, Ferdous Alam, Kathryn E. Waddell-Smith, Andrew D. McGavigan, Gemma Correnti, Eric Haan, Alex Brown, Jamie I. Vandenberg, Alfred L. George, Jr.

Research output: Contribution to journalArticle

Abstract

A 19-year-old Australian Indigenous woman presented after suffering a ventricular fibrillation cardiac arrest whilst swimming, leading to near drowning, in a remote Aboriginal community of South Australia. The patient was initially resuscitated by approximately 10 minutes of basic life support from a lifeguard, before receiving an automatic external defibrillation shock, and transferred to a regional intensive care unit where she received 24 hours of cooling. She retained normal cognitive function upon recovery. The patient had no prior history of palpitations, presyncope, or syncope. Inpatient ECG demonstrated a prolonged corrected QT interval (QTc) of 510 ms (Figure, A). QTc interval prolongation persisted during exercise and recovery. An echocardiogram and cardiac MRI demonstrated a structurally normal heart. A diagnosis of long QT syndrome was made, the patient was treated with a beta-blocker and an internal cardioverter defibrillator (ICD) was implanted. She has had no further clinical arrhythmias.
LanguageEnglish
JournalCirc Genom Precis Med
DOIs
Publication statusE-pub ahead of print - 2 Jan 2020

Keywords

  • Australia
  • Torres Strait Islanders
  • Aboriginal
  • Australian Indigenous
  • Patient

Cite this

Ganesan, A. N., Vanoye, C. G., Alam, F., Waddell-Smith, K. E., McGavigan, A. D., Correnti, G., ... George, Jr., A. L. (2020). Long QT Syndrome Type 1 in an Australian Indigenous Patient. Circ Genom Precis Med. https://doi.org/10.1161/CIRCGEN.119.002813
Ganesan, Anand N. ; Vanoye, Carlos G. ; Alam, Ferdous ; Waddell-Smith, Kathryn E. ; McGavigan, Andrew D. ; Correnti, Gemma ; Haan, Eric ; Brown, Alex ; Vandenberg, Jamie I. ; George, Jr., Alfred L. / Long QT Syndrome Type 1 in an Australian Indigenous Patient. In: Circ Genom Precis Med. 2020.
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Ganesan, AN, Vanoye, CG, Alam, F, Waddell-Smith, KE, McGavigan, AD, Correnti, G, Haan, E, Brown, A, Vandenberg, JI & George, Jr., AL 2020, 'Long QT Syndrome Type 1 in an Australian Indigenous Patient', Circ Genom Precis Med. https://doi.org/10.1161/CIRCGEN.119.002813

Long QT Syndrome Type 1 in an Australian Indigenous Patient. / Ganesan, Anand N. ; Vanoye, Carlos G.; Alam, Ferdous; Waddell-Smith, Kathryn E.; McGavigan, Andrew D.; Correnti, Gemma; Haan, Eric; Brown, Alex; Vandenberg, Jamie I.; George, Jr., Alfred L.

In: Circ Genom Precis Med, 02.01.2020.

Research output: Contribution to journalArticle

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AU - Vanoye, Carlos G.

AU - Alam, Ferdous

AU - Waddell-Smith, Kathryn E.

AU - McGavigan, Andrew D.

AU - Correnti, Gemma

AU - Haan, Eric

AU - Brown, Alex

AU - Vandenberg, Jamie I.

AU - George, Jr., Alfred L.

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N2 - A 19-year-old Australian Indigenous woman presented after suffering a ventricular fibrillation cardiac arrest whilst swimming, leading to near drowning, in a remote Aboriginal community of South Australia. The patient was initially resuscitated by approximately 10 minutes of basic life support from a lifeguard, before receiving an automatic external defibrillation shock, and transferred to a regional intensive care unit where she received 24 hours of cooling. She retained normal cognitive function upon recovery. The patient had no prior history of palpitations, presyncope, or syncope. Inpatient ECG demonstrated a prolonged corrected QT interval (QTc) of 510 ms (Figure, A). QTc interval prolongation persisted during exercise and recovery. An echocardiogram and cardiac MRI demonstrated a structurally normal heart. A diagnosis of long QT syndrome was made, the patient was treated with a beta-blocker and an internal cardioverter defibrillator (ICD) was implanted. She has had no further clinical arrhythmias.

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Ganesan AN, Vanoye CG, Alam F, Waddell-Smith KE, McGavigan AD, Correnti G et al. Long QT Syndrome Type 1 in an Australian Indigenous Patient. Circ Genom Precis Med. 2020 Jan 2. https://doi.org/10.1161/CIRCGEN.119.002813