Localization of HLA-ABC and DR antigens in human kidney

Derek N.J. Hart, Susan V. Fuggle, Keryn A. Williams, John W. Fabre, Alan Ting, Peter J. Morris

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Abstract

Monoclonal antibodies to human monomorphic class I and class II major histocompatibility complex (MHC) determinants have been used with immunofluorescence and immunoperoxidase techniques, to localize these an- tigens in normal human kidneys. HLA-DR antigen was located in the glomeruli (probably on endothelium as well as in the mesangium) and within the cells of cortical and medullary tubules. Dendritic cells in the renal inter- stitium stained brightly for the DR antigen and could be distinguished from the staining of capillary endothelium. The vascular endothelium of large vessels stained less densely for the HLA-DR antigen than for HLA-ABC an- tigens. The glomeruli stained intensely for the HLA-ABC antigens and diffuse staining of HLA-ABC antigens was also noted within renal tubular cells.

Original languageEnglish
Pages (from-to)428-433
Number of pages6
JournalTransplantation
Volume31
Issue number6
DOIs
Publication statusPublished - Jun 1981
Externally publishedYes

ASJC Scopus subject areas

  • Transplantation

Cite this

Hart, D. N. J., Fuggle, S. V., Williams, K. A., Fabre, J. W., Ting, A., & Morris, P. J. (1981). Localization of HLA-ABC and DR antigens in human kidney. Transplantation, 31(6), 428-433. https://doi.org/10.1097/00007890-198106000-00005