Lipidomic profiling before and after Roux-en-Y gastric bypass in obese patients with diabetes

J. Graessler, T. D. Bornstein, D. Goel, V. P. Bhalla, T. Lohmann, T. Wolf, M. Koch, Y. Qin, J. Licinio, M. L. Wong, T. Chavakis, A. Xu, A. Shevchenko, K. Schuhmann, P. E H Schwarz, K. M. Schulte, A. Patel, S. R. Bornstein

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Bariatric surgery is a well-established approach to improve metabolic disease in morbidly obese patients with high cardiovascular risk. The post-operative normalization of lipid metabolism has a central role in the prevention of future cardiovascular events. The aim of the present study therefore was to characterize changes of plasma lipidomic patterns, consisting of 229 lipid species of 13 lipid classes, 3 months after Roux-en-Y gastric bypass (RYGB) in morbidly obese patients with and without diabetes. RYGB resulted in a 15-32% decrease of body mass index, which was associated with a significant reduction of total cholesterol (TC, -28.3%; P=0.02), LDL-cholesterol (LDL-C, -26.8%; P=0.03) and triglycerides (TGs, -63.0%; P=0.05) measured by routine clinical chemistry. HDL-cholesterol remained unchanged. The effect of RYGB on the plasma lipidomic profile was characterized by significant decreases of 87 lipid species from triacylglycerides (TAGs), cholesterol esters (CholEs), lysophosphatidylcholines (LPCs), phosphatidylcholines (PCs), phosphatidylethanolamine ethers (PEOs), phosphatidylinositols (PIs) and ceramides (Cers). The total of plasma lipid components exhibited a substantial decline of 32.6% and 66 lipid species showed a decrease by over 50%. A direct correlation with HbA 1C values could be demonstrated for 24 individual lipid species (10 TAG, three CholE, two LPC, one lysophosphatidylcholine ethers (LPCO) (LPC ether), one PC, two phosphatidylcholine ethers (PCO) and five Cer). Notably, two lipid species (TAG 58:5 and PEO 40:5) were inversely correlated with HbA 1C. LPCO, as single whole lipid class, was directly related to HbA 1C. These data indicate that RYGB-induced modulation of lipidomic profiles provides important information about post-operative metabolic adaptations and might substantially contribute to improvements of glycemic control. These striking changes in the human plasma lipidome may explain acute, weight independent and long-term effects of RYGB on the cardiovascular system, mental status and immune regulation.

LanguageEnglish
Pages201-207
Number of pages7
JournalPharmacogenomics Journal
Volume14
Issue number3
DOIs
Publication statusPublished - 1 Jan 2014

Keywords

  • gastric bypass
  • lipidomics
  • plasma lipidomic profile
  • type-2 diabetes mellitus

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Pharmacology

Cite this

Graessler, J., Bornstein, T. D., Goel, D., Bhalla, V. P., Lohmann, T., Wolf, T., ... Bornstein, S. R. (2014). Lipidomic profiling before and after Roux-en-Y gastric bypass in obese patients with diabetes. Pharmacogenomics Journal, 14(3), 201-207. https://doi.org/10.1038/tpj.2013.42
Graessler, J. ; Bornstein, T. D. ; Goel, D. ; Bhalla, V. P. ; Lohmann, T. ; Wolf, T. ; Koch, M. ; Qin, Y. ; Licinio, J. ; Wong, M. L. ; Chavakis, T. ; Xu, A. ; Shevchenko, A. ; Schuhmann, K. ; Schwarz, P. E H ; Schulte, K. M. ; Patel, A. ; Bornstein, S. R. / Lipidomic profiling before and after Roux-en-Y gastric bypass in obese patients with diabetes. In: Pharmacogenomics Journal. 2014 ; Vol. 14, No. 3. pp. 201-207.
@article{206adb10350d4d398ef074d11e3633e2,
title = "Lipidomic profiling before and after Roux-en-Y gastric bypass in obese patients with diabetes",
abstract = "Bariatric surgery is a well-established approach to improve metabolic disease in morbidly obese patients with high cardiovascular risk. The post-operative normalization of lipid metabolism has a central role in the prevention of future cardiovascular events. The aim of the present study therefore was to characterize changes of plasma lipidomic patterns, consisting of 229 lipid species of 13 lipid classes, 3 months after Roux-en-Y gastric bypass (RYGB) in morbidly obese patients with and without diabetes. RYGB resulted in a 15-32{\%} decrease of body mass index, which was associated with a significant reduction of total cholesterol (TC, -28.3{\%}; P=0.02), LDL-cholesterol (LDL-C, -26.8{\%}; P=0.03) and triglycerides (TGs, -63.0{\%}; P=0.05) measured by routine clinical chemistry. HDL-cholesterol remained unchanged. The effect of RYGB on the plasma lipidomic profile was characterized by significant decreases of 87 lipid species from triacylglycerides (TAGs), cholesterol esters (CholEs), lysophosphatidylcholines (LPCs), phosphatidylcholines (PCs), phosphatidylethanolamine ethers (PEOs), phosphatidylinositols (PIs) and ceramides (Cers). The total of plasma lipid components exhibited a substantial decline of 32.6{\%} and 66 lipid species showed a decrease by over 50{\%}. A direct correlation with HbA 1C values could be demonstrated for 24 individual lipid species (10 TAG, three CholE, two LPC, one lysophosphatidylcholine ethers (LPCO) (LPC ether), one PC, two phosphatidylcholine ethers (PCO) and five Cer). Notably, two lipid species (TAG 58:5 and PEO 40:5) were inversely correlated with HbA 1C. LPCO, as single whole lipid class, was directly related to HbA 1C. These data indicate that RYGB-induced modulation of lipidomic profiles provides important information about post-operative metabolic adaptations and might substantially contribute to improvements of glycemic control. These striking changes in the human plasma lipidome may explain acute, weight independent and long-term effects of RYGB on the cardiovascular system, mental status and immune regulation.",
keywords = "gastric bypass, lipidomics, plasma lipidomic profile, type-2 diabetes mellitus",
author = "J. Graessler and Bornstein, {T. D.} and D. Goel and Bhalla, {V. P.} and T. Lohmann and T. Wolf and M. Koch and Y. Qin and J. Licinio and Wong, {M. L.} and T. Chavakis and A. Xu and A. Shevchenko and K. Schuhmann and Schwarz, {P. E H} and Schulte, {K. M.} and A. Patel and Bornstein, {S. R.}",
year = "2014",
month = "1",
day = "1",
doi = "10.1038/tpj.2013.42",
language = "English",
volume = "14",
pages = "201--207",
journal = "Pharmacogenomics Journal",
issn = "1470-269X",
publisher = "Nature Publishing Group",
number = "3",

}

Graessler, J, Bornstein, TD, Goel, D, Bhalla, VP, Lohmann, T, Wolf, T, Koch, M, Qin, Y, Licinio, J, Wong, ML, Chavakis, T, Xu, A, Shevchenko, A, Schuhmann, K, Schwarz, PEH, Schulte, KM, Patel, A & Bornstein, SR 2014, 'Lipidomic profiling before and after Roux-en-Y gastric bypass in obese patients with diabetes', Pharmacogenomics Journal, vol. 14, no. 3, pp. 201-207. https://doi.org/10.1038/tpj.2013.42

Lipidomic profiling before and after Roux-en-Y gastric bypass in obese patients with diabetes. / Graessler, J.; Bornstein, T. D.; Goel, D.; Bhalla, V. P.; Lohmann, T.; Wolf, T.; Koch, M.; Qin, Y.; Licinio, J.; Wong, M. L.; Chavakis, T.; Xu, A.; Shevchenko, A.; Schuhmann, K.; Schwarz, P. E H; Schulte, K. M.; Patel, A.; Bornstein, S. R.

In: Pharmacogenomics Journal, Vol. 14, No. 3, 01.01.2014, p. 201-207.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Lipidomic profiling before and after Roux-en-Y gastric bypass in obese patients with diabetes

AU - Graessler, J.

AU - Bornstein, T. D.

AU - Goel, D.

AU - Bhalla, V. P.

AU - Lohmann, T.

AU - Wolf, T.

AU - Koch, M.

AU - Qin, Y.

AU - Licinio, J.

AU - Wong, M. L.

AU - Chavakis, T.

AU - Xu, A.

AU - Shevchenko, A.

AU - Schuhmann, K.

AU - Schwarz, P. E H

AU - Schulte, K. M.

AU - Patel, A.

AU - Bornstein, S. R.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Bariatric surgery is a well-established approach to improve metabolic disease in morbidly obese patients with high cardiovascular risk. The post-operative normalization of lipid metabolism has a central role in the prevention of future cardiovascular events. The aim of the present study therefore was to characterize changes of plasma lipidomic patterns, consisting of 229 lipid species of 13 lipid classes, 3 months after Roux-en-Y gastric bypass (RYGB) in morbidly obese patients with and without diabetes. RYGB resulted in a 15-32% decrease of body mass index, which was associated with a significant reduction of total cholesterol (TC, -28.3%; P=0.02), LDL-cholesterol (LDL-C, -26.8%; P=0.03) and triglycerides (TGs, -63.0%; P=0.05) measured by routine clinical chemistry. HDL-cholesterol remained unchanged. The effect of RYGB on the plasma lipidomic profile was characterized by significant decreases of 87 lipid species from triacylglycerides (TAGs), cholesterol esters (CholEs), lysophosphatidylcholines (LPCs), phosphatidylcholines (PCs), phosphatidylethanolamine ethers (PEOs), phosphatidylinositols (PIs) and ceramides (Cers). The total of plasma lipid components exhibited a substantial decline of 32.6% and 66 lipid species showed a decrease by over 50%. A direct correlation with HbA 1C values could be demonstrated for 24 individual lipid species (10 TAG, three CholE, two LPC, one lysophosphatidylcholine ethers (LPCO) (LPC ether), one PC, two phosphatidylcholine ethers (PCO) and five Cer). Notably, two lipid species (TAG 58:5 and PEO 40:5) were inversely correlated with HbA 1C. LPCO, as single whole lipid class, was directly related to HbA 1C. These data indicate that RYGB-induced modulation of lipidomic profiles provides important information about post-operative metabolic adaptations and might substantially contribute to improvements of glycemic control. These striking changes in the human plasma lipidome may explain acute, weight independent and long-term effects of RYGB on the cardiovascular system, mental status and immune regulation.

AB - Bariatric surgery is a well-established approach to improve metabolic disease in morbidly obese patients with high cardiovascular risk. The post-operative normalization of lipid metabolism has a central role in the prevention of future cardiovascular events. The aim of the present study therefore was to characterize changes of plasma lipidomic patterns, consisting of 229 lipid species of 13 lipid classes, 3 months after Roux-en-Y gastric bypass (RYGB) in morbidly obese patients with and without diabetes. RYGB resulted in a 15-32% decrease of body mass index, which was associated with a significant reduction of total cholesterol (TC, -28.3%; P=0.02), LDL-cholesterol (LDL-C, -26.8%; P=0.03) and triglycerides (TGs, -63.0%; P=0.05) measured by routine clinical chemistry. HDL-cholesterol remained unchanged. The effect of RYGB on the plasma lipidomic profile was characterized by significant decreases of 87 lipid species from triacylglycerides (TAGs), cholesterol esters (CholEs), lysophosphatidylcholines (LPCs), phosphatidylcholines (PCs), phosphatidylethanolamine ethers (PEOs), phosphatidylinositols (PIs) and ceramides (Cers). The total of plasma lipid components exhibited a substantial decline of 32.6% and 66 lipid species showed a decrease by over 50%. A direct correlation with HbA 1C values could be demonstrated for 24 individual lipid species (10 TAG, three CholE, two LPC, one lysophosphatidylcholine ethers (LPCO) (LPC ether), one PC, two phosphatidylcholine ethers (PCO) and five Cer). Notably, two lipid species (TAG 58:5 and PEO 40:5) were inversely correlated with HbA 1C. LPCO, as single whole lipid class, was directly related to HbA 1C. These data indicate that RYGB-induced modulation of lipidomic profiles provides important information about post-operative metabolic adaptations and might substantially contribute to improvements of glycemic control. These striking changes in the human plasma lipidome may explain acute, weight independent and long-term effects of RYGB on the cardiovascular system, mental status and immune regulation.

KW - gastric bypass

KW - lipidomics

KW - plasma lipidomic profile

KW - type-2 diabetes mellitus

UR - http://www.scopus.com/inward/record.url?scp=84901272077&partnerID=8YFLogxK

U2 - 10.1038/tpj.2013.42

DO - 10.1038/tpj.2013.42

M3 - Article

VL - 14

SP - 201

EP - 207

JO - Pharmacogenomics Journal

T2 - Pharmacogenomics Journal

JF - Pharmacogenomics Journal

SN - 1470-269X

IS - 3

ER -