Neural crest cells are a transient population of stem cells that give rise to a diverse range of cell types during embryonic development. Through gain-of-function and loss-of-function studies in several model organisms many key signalling pathways and cell-type specific transcription factors essential for neural crest cell development have been identified. However, the role of post-translational regulation remains largely unexplored. Here we review this cell type with a foray into the known and potential roles of the ubiquitination pathway in key signalling events during neural crest cell development.
|Number of pages||5|
|Journal||International Journal of Biochemistry and Cell Biology|
|Publication status||Published - 1 Jan 2013|
- Neural crest
- Stem cell
ASJC Scopus subject areas
- Cell Biology