Lessons from coronary intravascular ultrasound on the importance of raising high-density lipoprotein cholesterol

Stephen J. Nicholls, Kiyoko Uno, E. Murat Tuzcu, Steven E. Nissen

Research output: Contribution to journalReview articlepeer-review

9 Citations (Scopus)


Technological advances have enhanced our ability to visualize the entire extent of atherosclerosis within the artery wall. Intravascular ultrasound has enabled characterization of the impact of medical therapies on progression of coronary atherosclerosis. Despite use of established anti-atherosclerotic therapy, cardiovascular disease still remains the leading cause of morbidity and mortality. There is an ongoing need to develop new therapeutic strategies to achieve more effective reduction in cardiovascular risk. Raising high-density lipoprotein cholesterol continues to receive attention as a therapeutic strategy. The relationship between high-density lipoprotein and progression of atherosclerosis and its implications for clinical practice are reviewed here.

Original languageEnglish
Pages (from-to)301-307
Number of pages7
JournalCurrent Atherosclerosis Reports
Issue number5
Publication statusPublished - 1 Sep 2010


  • Atherosclerosis
  • HDL
  • Imaging
  • Intravascular ultrasound
  • Risk factors

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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