Leishmania: conserved evolution - diverse diseases

Miriam A. Lynn, W. Robert McMaster

Research output: Contribution to journalReview article

23 Citations (Scopus)

Abstract

The landmark completion of the Leishmania major genome sequence and the recent publication of the L. infantum and L. braziliensis genomes revealed the surprising result that, although separated by 15-50 million years of evolution, the Leishmania genomes are highly conserved and have less than 1% species-specific genes. Yet, these three species of Leishmania cause distinctive and diverse diseases in humans. Here, we discuss these findings together with recent microarray and proteomics studies and highlight their importance in understanding Leishmania disease phenotypes.

LanguageEnglish
Pages103-105
Number of pages3
JournalTrends in Parasitology
Volume24
Issue number3
DOIs
Publication statusPublished - 24 Mar 2008
Externally publishedYes

Keywords

  • Leishmania
  • microarray
  • proteomics

ASJC Scopus subject areas

  • Infectious Diseases
  • Parasitology

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