Joint association of magnesium and iron intake with anemia among Chinese adults

Zumin Shi, Xiaoshu Hu, Ka He, Baojun Yuan, Manohar Garg

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Objective: Inflammation and iron deficiency are two important causes of anemia. Magnesium intake is inversely associated with inflammation. However, little is known as to whether magnesium intake is related to anemia. We assessed the joint association of magnesium and iron intake with anemia among Chinese adults. Methods: A cross-sectional household survey of 2849 men and women 20 y of age or older was conducted in 2002. Nutrient intakes were assessed by 3-d weighed food records. Serum ferritin and hemoglobin concentrations were measured. Results: The prevalence of anemia was 18.3% in men and 31.5% in women. Magnesium and iron intakes were positively associated with hemoglobin levels and inversely related to the prevalence of anemia. The risks of anemia were reduced by 26% (P for trend = 0.03) and 52% (P < 0.01), respectively, for iron and magnesium intake comparing the fourth quartile with the first with adjustment for potential confounders. The lowest risk of anemia was observed among participants with the highest intakes of magnesium and iron (odds ratio 0.46, 95% confidence interval 0.31-0.68). The inverse association of iron intake and anemia but not the association of magnesium intake and anemia was modified by serum ferritin levels. The observed relations were not appreciably modified by gender. Conclusion: This study suggests that magnesium is a potent predictor of anemia in Chinese adults.

LanguageEnglish
Pages977-984
Number of pages8
JournalNutrition
Volume24
Issue number10
DOIs
Publication statusPublished - Oct 2008

Keywords

  • Anemia
  • Chinese
  • Epidemiology
  • Iron
  • Magnesium

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Shi, Zumin ; Hu, Xiaoshu ; He, Ka ; Yuan, Baojun ; Garg, Manohar. / Joint association of magnesium and iron intake with anemia among Chinese adults. In: Nutrition. 2008 ; Vol. 24, No. 10. pp. 977-984.
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abstract = "Objective: Inflammation and iron deficiency are two important causes of anemia. Magnesium intake is inversely associated with inflammation. However, little is known as to whether magnesium intake is related to anemia. We assessed the joint association of magnesium and iron intake with anemia among Chinese adults. Methods: A cross-sectional household survey of 2849 men and women 20 y of age or older was conducted in 2002. Nutrient intakes were assessed by 3-d weighed food records. Serum ferritin and hemoglobin concentrations were measured. Results: The prevalence of anemia was 18.3{\%} in men and 31.5{\%} in women. Magnesium and iron intakes were positively associated with hemoglobin levels and inversely related to the prevalence of anemia. The risks of anemia were reduced by 26{\%} (P for trend = 0.03) and 52{\%} (P < 0.01), respectively, for iron and magnesium intake comparing the fourth quartile with the first with adjustment for potential confounders. The lowest risk of anemia was observed among participants with the highest intakes of magnesium and iron (odds ratio 0.46, 95{\%} confidence interval 0.31-0.68). The inverse association of iron intake and anemia but not the association of magnesium intake and anemia was modified by serum ferritin levels. The observed relations were not appreciably modified by gender. Conclusion: This study suggests that magnesium is a potent predictor of anemia in Chinese adults.",
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Joint association of magnesium and iron intake with anemia among Chinese adults. / Shi, Zumin; Hu, Xiaoshu; He, Ka; Yuan, Baojun; Garg, Manohar.

In: Nutrition, Vol. 24, No. 10, 10.2008, p. 977-984.

Research output: Contribution to journalArticle

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T1 - Joint association of magnesium and iron intake with anemia among Chinese adults

AU - Shi, Zumin

AU - Hu, Xiaoshu

AU - He, Ka

AU - Yuan, Baojun

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AB - Objective: Inflammation and iron deficiency are two important causes of anemia. Magnesium intake is inversely associated with inflammation. However, little is known as to whether magnesium intake is related to anemia. We assessed the joint association of magnesium and iron intake with anemia among Chinese adults. Methods: A cross-sectional household survey of 2849 men and women 20 y of age or older was conducted in 2002. Nutrient intakes were assessed by 3-d weighed food records. Serum ferritin and hemoglobin concentrations were measured. Results: The prevalence of anemia was 18.3% in men and 31.5% in women. Magnesium and iron intakes were positively associated with hemoglobin levels and inversely related to the prevalence of anemia. The risks of anemia were reduced by 26% (P for trend = 0.03) and 52% (P < 0.01), respectively, for iron and magnesium intake comparing the fourth quartile with the first with adjustment for potential confounders. The lowest risk of anemia was observed among participants with the highest intakes of magnesium and iron (odds ratio 0.46, 95% confidence interval 0.31-0.68). The inverse association of iron intake and anemia but not the association of magnesium intake and anemia was modified by serum ferritin levels. The observed relations were not appreciably modified by gender. Conclusion: This study suggests that magnesium is a potent predictor of anemia in Chinese adults.

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