Is There a Role for Neural Crest Stem Cells in Periodontal Regeneration?

Atsushi Tomokiyo, Kim Hynes, Stan Gronthos, Naohisa Wada, P. Mark Bartold

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)

Abstract

The ultimate goal of periodontal treatment is not only the stabilization of periodontal disease but also regeneration of the periodontal tissues destroyed by severe periodontitis. The tissue engineering triad of stem cells, biological signals, and cell-seeded scaffold provides a biological template for tissue regeneration. Neural crest stem cells (NCSC) comprise a transient multipotent stem cell population that initially emerges from the junction of the epidermal and neural ectoderm through reciprocal interactions between these tissues and signals from the mesoderm during embryonic development of vertebrates. The cells then migrate to their destination in the embryo and differentiate into various dental mesenchymal stem cells which give rise to most components of the dental tissues, including periodontal ligament (PDL), alveolar bone, cementum, dental pulp, and dentin. The crucial role that NCSC play in embryonic development makes them a highly promising stem cell population for use in the regeneration of periodontal tissues. Here, we review the current understanding of the features and functions of NCSC-derived cells in dental tissues. We additionally discuss the possibility that NCSC contribute to the regeneration of periodontal tissues.

Original languageEnglish
Pages (from-to)275-281
Number of pages7
JournalCurrent Oral Health Reports
Volume2
Issue number4
DOIs
Publication statusPublished or Issued - Dec 2015
Externally publishedYes

Keywords

  • Dental stem cells
  • Multipotency
  • Neural crest
  • Regeneration
  • Self-renewal
  • Tooth

ASJC Scopus subject areas

  • Immunology and Microbiology (miscellaneous)
  • Oral Surgery
  • Surgery

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