Is short first-trimester crown-rump length associated with spontaneous preterm birth?

B. M. Kazemier, C. E. Kleinrouweler, M. A. Oudijk, J. A M Van Der Post, B. W J Mol, J. Y. Vis, E. Pajkrt

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective To assess the association between first-trimester crown-rump length (CRL) and the risk of spontaneous preterm birth before 32 weeks' gestation. Methods We performed a matched case-control study of 129 women with spontaneous preterm birth at < 32 weeks' gestation (cases) and 129 women with term deliveries (controls) using data stored in the ultrasound and obstetric databases of our tertiary referral center. Cases and controls were individually matched based on maternal age, parity, history of preterm birth and medical indication for antenatal care. Fetal CRL measured between 8 + 0 and 13 + 6 weeks was expressed as multiples of the median (MoM) expected CRL, based on last menstrual period. We investigated the association between CRL-MoM and spontaneous preterm birth using logistic regression analysis. Results CRL-MoM was not associated with spontaneous preterm birth: odds ratio (OR) 1.10 (95% CI, 0.89-1.36) per 0.10 MoM increase in CRL. Timing of measurement did not influence the model (P = 0.59). This was confirmed when restricting the analysis to the 93 pairs with CRL measurements made between 10 + 0 and 13 + 6 weeks: OR for preterm birth 1.07 (95% CI, 0.83-1.37) per 0.10 MoM increase in CRL. Conclusion A short CRL in the first trimester is not associated with spontaneous preterm birth before 32 weeks' gestation, thus short CRL cannot be used to identify women at increased risk of preterm birth.

LanguageEnglish
Pages636-641
Number of pages6
JournalUltrasound in Obstetrics and Gynecology
Volume40
Issue number6
DOIs
Publication statusPublished - Dec 2012

Keywords

  • CRL
  • first trimester
  • prediction
  • spontaneous preterm birth
  • ultrasound

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Reproductive Medicine
  • Medicine(all)

Cite this

Kazemier, B. M., Kleinrouweler, C. E., Oudijk, M. A., Van Der Post, J. A. M., Mol, B. W. J., Vis, J. Y., & Pajkrt, E. (2012). Is short first-trimester crown-rump length associated with spontaneous preterm birth? Ultrasound in Obstetrics and Gynecology, 40(6), 636-641. https://doi.org/10.1002/uog.11148
Kazemier, B. M. ; Kleinrouweler, C. E. ; Oudijk, M. A. ; Van Der Post, J. A M ; Mol, B. W J ; Vis, J. Y. ; Pajkrt, E. / Is short first-trimester crown-rump length associated with spontaneous preterm birth?. In: Ultrasound in Obstetrics and Gynecology. 2012 ; Vol. 40, No. 6. pp. 636-641.
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abstract = "Objective To assess the association between first-trimester crown-rump length (CRL) and the risk of spontaneous preterm birth before 32 weeks' gestation. Methods We performed a matched case-control study of 129 women with spontaneous preterm birth at < 32 weeks' gestation (cases) and 129 women with term deliveries (controls) using data stored in the ultrasound and obstetric databases of our tertiary referral center. Cases and controls were individually matched based on maternal age, parity, history of preterm birth and medical indication for antenatal care. Fetal CRL measured between 8 + 0 and 13 + 6 weeks was expressed as multiples of the median (MoM) expected CRL, based on last menstrual period. We investigated the association between CRL-MoM and spontaneous preterm birth using logistic regression analysis. Results CRL-MoM was not associated with spontaneous preterm birth: odds ratio (OR) 1.10 (95{\%} CI, 0.89-1.36) per 0.10 MoM increase in CRL. Timing of measurement did not influence the model (P = 0.59). This was confirmed when restricting the analysis to the 93 pairs with CRL measurements made between 10 + 0 and 13 + 6 weeks: OR for preterm birth 1.07 (95{\%} CI, 0.83-1.37) per 0.10 MoM increase in CRL. Conclusion A short CRL in the first trimester is not associated with spontaneous preterm birth before 32 weeks' gestation, thus short CRL cannot be used to identify women at increased risk of preterm birth.",
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Kazemier, BM, Kleinrouweler, CE, Oudijk, MA, Van Der Post, JAM, Mol, BWJ, Vis, JY & Pajkrt, E 2012, 'Is short first-trimester crown-rump length associated with spontaneous preterm birth?', Ultrasound in Obstetrics and Gynecology, vol. 40, no. 6, pp. 636-641. https://doi.org/10.1002/uog.11148

Is short first-trimester crown-rump length associated with spontaneous preterm birth? / Kazemier, B. M.; Kleinrouweler, C. E.; Oudijk, M. A.; Van Der Post, J. A M; Mol, B. W J; Vis, J. Y.; Pajkrt, E.

In: Ultrasound in Obstetrics and Gynecology, Vol. 40, No. 6, 12.2012, p. 636-641.

Research output: Contribution to journalArticle

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N2 - Objective To assess the association between first-trimester crown-rump length (CRL) and the risk of spontaneous preterm birth before 32 weeks' gestation. Methods We performed a matched case-control study of 129 women with spontaneous preterm birth at < 32 weeks' gestation (cases) and 129 women with term deliveries (controls) using data stored in the ultrasound and obstetric databases of our tertiary referral center. Cases and controls were individually matched based on maternal age, parity, history of preterm birth and medical indication for antenatal care. Fetal CRL measured between 8 + 0 and 13 + 6 weeks was expressed as multiples of the median (MoM) expected CRL, based on last menstrual period. We investigated the association between CRL-MoM and spontaneous preterm birth using logistic regression analysis. Results CRL-MoM was not associated with spontaneous preterm birth: odds ratio (OR) 1.10 (95% CI, 0.89-1.36) per 0.10 MoM increase in CRL. Timing of measurement did not influence the model (P = 0.59). This was confirmed when restricting the analysis to the 93 pairs with CRL measurements made between 10 + 0 and 13 + 6 weeks: OR for preterm birth 1.07 (95% CI, 0.83-1.37) per 0.10 MoM increase in CRL. Conclusion A short CRL in the first trimester is not associated with spontaneous preterm birth before 32 weeks' gestation, thus short CRL cannot be used to identify women at increased risk of preterm birth.

AB - Objective To assess the association between first-trimester crown-rump length (CRL) and the risk of spontaneous preterm birth before 32 weeks' gestation. Methods We performed a matched case-control study of 129 women with spontaneous preterm birth at < 32 weeks' gestation (cases) and 129 women with term deliveries (controls) using data stored in the ultrasound and obstetric databases of our tertiary referral center. Cases and controls were individually matched based on maternal age, parity, history of preterm birth and medical indication for antenatal care. Fetal CRL measured between 8 + 0 and 13 + 6 weeks was expressed as multiples of the median (MoM) expected CRL, based on last menstrual period. We investigated the association between CRL-MoM and spontaneous preterm birth using logistic regression analysis. Results CRL-MoM was not associated with spontaneous preterm birth: odds ratio (OR) 1.10 (95% CI, 0.89-1.36) per 0.10 MoM increase in CRL. Timing of measurement did not influence the model (P = 0.59). This was confirmed when restricting the analysis to the 93 pairs with CRL measurements made between 10 + 0 and 13 + 6 weeks: OR for preterm birth 1.07 (95% CI, 0.83-1.37) per 0.10 MoM increase in CRL. Conclusion A short CRL in the first trimester is not associated with spontaneous preterm birth before 32 weeks' gestation, thus short CRL cannot be used to identify women at increased risk of preterm birth.

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KW - first trimester

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Kazemier BM, Kleinrouweler CE, Oudijk MA, Van Der Post JAM, Mol BWJ, Vis JY et al. Is short first-trimester crown-rump length associated with spontaneous preterm birth? Ultrasound in Obstetrics and Gynecology. 2012 Dec;40(6):636-641. https://doi.org/10.1002/uog.11148