Is it useful to measure C-reactive protein and leukocytes in patients with prelabor rupture of membranes?

Jantien L. Van Der Heyden, Stijn S P Van Teeffelen, Anne C G Coolen, Feico J. Halbertsma, Robert Aardenburg, Helena J M M Mertens, Ben Willem J Mol

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Neonatal infection is the main complication of prelabor rupture of membranes (PROM). We studied the accuracy of measuring C-reactive protein (CRP) and leukocytes in maternal serum to predict neonatal infection. We performed a retrospective cohort study in two hospitals in the Netherlands between 2003 and 2006. We included consecutive women hospitalized for PROM. In both hospitals, CRP and leukocytes were measured routinely in maternal serum every 2 days until delivery. End points considered were clinical neonatal infection and proven neonatal sepsis. The accuracy of CRP and leukocytes was assessed using receiver operating characteristic (ROC) analysis. We included 299 women with PROM, 12 of whom had a twin pregnancy. Gestational age at inclusion varied between 26 weeks and 0 days and 41 weeks and 5 days with a median of 37 weeks and 3 days. In 47 women (16%), the neonate developed a clinical infection. The areas under the ROC curve of CRP and leukocytes in the prediction of clinical neonatal infection were 0.61 and 0.62, respectively. Of the 47 infected neonates, six neonates (2%) had a proven neonatal sepsis. In the mothers of these septic neonates, maternal CRP did not rise above 50 mg/L and leukocyte values varied between 9.8 and 25.8×109/L. In women with PROM, CRP and leukocytes should not be measured routinely.

LanguageEnglish
Pages543-547
Number of pages5
JournalAmerican Journal of Perinatology
Volume27
Issue number7
DOIs
Publication statusPublished - 29 Jul 2010

Keywords

  • CRP and leukocytes
  • PROM
  • neonatal infection

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology

Cite this

Van Der Heyden, J. L., Van Teeffelen, S. S. P., Coolen, A. C. G., Halbertsma, F. J., Aardenburg, R., Mertens, H. J. M. M., & Mol, B. W. J. (2010). Is it useful to measure C-reactive protein and leukocytes in patients with prelabor rupture of membranes? American Journal of Perinatology, 27(7), 543-547. https://doi.org/10.1055/s-0030-1248941
Van Der Heyden, Jantien L. ; Van Teeffelen, Stijn S P ; Coolen, Anne C G ; Halbertsma, Feico J. ; Aardenburg, Robert ; Mertens, Helena J M M ; Mol, Ben Willem J. / Is it useful to measure C-reactive protein and leukocytes in patients with prelabor rupture of membranes?. In: American Journal of Perinatology. 2010 ; Vol. 27, No. 7. pp. 543-547.
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Van Der Heyden, JL, Van Teeffelen, SSP, Coolen, ACG, Halbertsma, FJ, Aardenburg, R, Mertens, HJMM & Mol, BWJ 2010, 'Is it useful to measure C-reactive protein and leukocytes in patients with prelabor rupture of membranes?', American Journal of Perinatology, vol. 27, no. 7, pp. 543-547. https://doi.org/10.1055/s-0030-1248941

Is it useful to measure C-reactive protein and leukocytes in patients with prelabor rupture of membranes? / Van Der Heyden, Jantien L.; Van Teeffelen, Stijn S P; Coolen, Anne C G; Halbertsma, Feico J.; Aardenburg, Robert; Mertens, Helena J M M; Mol, Ben Willem J.

In: American Journal of Perinatology, Vol. 27, No. 7, 29.07.2010, p. 543-547.

Research output: Contribution to journalArticle

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Van Der Heyden JL, Van Teeffelen SSP, Coolen ACG, Halbertsma FJ, Aardenburg R, Mertens HJMM et al. Is it useful to measure C-reactive protein and leukocytes in patients with prelabor rupture of membranes? American Journal of Perinatology. 2010 Jul 29;27(7):543-547. https://doi.org/10.1055/s-0030-1248941