Is grand multiparity associated with an increased risk of dysglycaemia?

D. Simmons, J. Shaw, A. McKenzie, S. Eaton, A. J. Cameron, P. Zimmet

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Aims/hypothesis: We sought to determine the risk of diabetes and IGT/IFG with grand multiparity. Subjects, materials and methods: Women, aged ≥25 years, from the Australian Diabetes, Obesity and Lifestyle Study and the Crossroads Undiagnosed Disease Study (a rural study in Victoria, Australia), participated in a household census (response 67 and 70%, respectively), subsequently attending a biomedical examination that included an oral glucose tolerance test (58% [6198] and 69% [819]). Results: After adjusting for age, obesity and socio-economic status, diabetes, but not IGT/IFG, was less common among women with a parity of 1 to 2 (odds ratio [OR]=0.64 [0.48-0.84]) and 3 to 4 (OR=0.72 [0.53-0.96]) than in grand multiparous women. This relationship was unrelated to past hysterectomy, use of the oral contraceptive pill or menopausal status. Conclusions/interpretation: Grand multiparity is associated with an increased risk of diabetes but not of IGT/IFG. We postulate that parity accelerates transition from IGT/IFG to diabetes, more than it does transition from normal glucose tolerance to IGT/IFG.

LanguageEnglish
Pages1522-1527
Number of pages6
JournalDiabetologia
Volume49
Issue number7
DOIs
Publication statusPublished - 1 Jul 2006
Externally publishedYes

Keywords

  • Diabetes
  • Hysterectomy
  • Menopause
  • Oral contraceptive pill
  • Parity

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Simmons, D., Shaw, J., McKenzie, A., Eaton, S., Cameron, A. J., & Zimmet, P. (2006). Is grand multiparity associated with an increased risk of dysglycaemia? Diabetologia, 49(7), 1522-1527. https://doi.org/10.1007/s00125-006-0276-6
Simmons, D. ; Shaw, J. ; McKenzie, A. ; Eaton, S. ; Cameron, A. J. ; Zimmet, P. / Is grand multiparity associated with an increased risk of dysglycaemia?. In: Diabetologia. 2006 ; Vol. 49, No. 7. pp. 1522-1527.
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Simmons, D, Shaw, J, McKenzie, A, Eaton, S, Cameron, AJ & Zimmet, P 2006, 'Is grand multiparity associated with an increased risk of dysglycaemia?', Diabetologia, vol. 49, no. 7, pp. 1522-1527. https://doi.org/10.1007/s00125-006-0276-6

Is grand multiparity associated with an increased risk of dysglycaemia? / Simmons, D.; Shaw, J.; McKenzie, A.; Eaton, S.; Cameron, A. J.; Zimmet, P.

In: Diabetologia, Vol. 49, No. 7, 01.07.2006, p. 1522-1527.

Research output: Contribution to journalArticle

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Simmons D, Shaw J, McKenzie A, Eaton S, Cameron AJ, Zimmet P. Is grand multiparity associated with an increased risk of dysglycaemia? Diabetologia. 2006 Jul 1;49(7):1522-1527. https://doi.org/10.1007/s00125-006-0276-6