Is aspirin effective in women undergoing in vitro fertilization (IVF)? Results from an individual patient data meta-analysis (IPD MA)

E. Groeneveld, K. A. Broeze, M. J. Lambers, M. Haapsamo, K. Dirckx, B. C. Schoot, B. Salle, C. I. Duvan, R. Schats, B. W. Mol, P. G A Hompes

Research output: Contribution to journalArticle

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Abstract

Background: Aspirin is believed to improve the outcome of IVF, but previous conventional meta-analyses on the subject are conflicting. Therefore, we performed a meta-analysis with individual patient data (IPD MA) of randomized clinical trials (RCTs) on the subject. Methods: A systematic literature search was conducted to identify RCTs assessing the effectiveness of aspirin in IVF. Authors were asked to share their original data. In a one step meta-analytic approach, the treatment effect of aspirin was estimated with odds ratios (ORs) and 95% confidence intervals (CIs) using logistic regression, based on the intention to treat principle. Results: Ten studies fulfilled the inclusion criteria. Authors of six studies provided IPD, including 1119 patients (562 placebo and 557 aspirin). There were 160 clinical pregnancies in the aspirin (28.8%) and 179 (31.9%) in the placebo group [OR 0.86, 95% CI (0.69-1.1)]. There were 129 ongoing pregnancies in the aspirin (23.6%) and 147 in the placebo group (26.7%) [OR 0.85, 95% CI (0.65-1.1)]. Whereas the conventional meta-analysis limited to studies that could provide IPD showed an OR of 0.89 (95% CI 0.69-1.2), the conventional meta-analysis limited to the eight studies of which method of randomization could be confirmed showed an OR of 0.94 (95% CI 0.76-1.17) and the conventional meta-analysis including all 10 eligible RCTs identified with our search changed the OR to 1.07 (95% CI 0.81-1.41). This difference in direction of effect, derived from the studies not able to share IPD of which quality of randomization could not be confirmed. Conclusions: Aspirin does not improve pregnancy rates after IVF.

LanguageEnglish
Article numberdmr007
Pages501-509
Number of pages9
JournalHuman Reproduction Update
Volume17
Issue number4
DOIs
Publication statusPublished - 1 Jul 2011

Keywords

  • Aspirin
  • In vitro fertilization
  • Individual patient data meta-analysis

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

Cite this

Groeneveld, E., Broeze, K. A., Lambers, M. J., Haapsamo, M., Dirckx, K., Schoot, B. C., ... Hompes, P. G. A. (2011). Is aspirin effective in women undergoing in vitro fertilization (IVF)? Results from an individual patient data meta-analysis (IPD MA). Human Reproduction Update, 17(4), 501-509. [dmr007]. https://doi.org/10.1093/humupd/dmr007
Groeneveld, E. ; Broeze, K. A. ; Lambers, M. J. ; Haapsamo, M. ; Dirckx, K. ; Schoot, B. C. ; Salle, B. ; Duvan, C. I. ; Schats, R. ; Mol, B. W. ; Hompes, P. G A. / Is aspirin effective in women undergoing in vitro fertilization (IVF)? Results from an individual patient data meta-analysis (IPD MA). In: Human Reproduction Update. 2011 ; Vol. 17, No. 4. pp. 501-509.
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abstract = "Background: Aspirin is believed to improve the outcome of IVF, but previous conventional meta-analyses on the subject are conflicting. Therefore, we performed a meta-analysis with individual patient data (IPD MA) of randomized clinical trials (RCTs) on the subject. Methods: A systematic literature search was conducted to identify RCTs assessing the effectiveness of aspirin in IVF. Authors were asked to share their original data. In a one step meta-analytic approach, the treatment effect of aspirin was estimated with odds ratios (ORs) and 95{\%} confidence intervals (CIs) using logistic regression, based on the intention to treat principle. Results: Ten studies fulfilled the inclusion criteria. Authors of six studies provided IPD, including 1119 patients (562 placebo and 557 aspirin). There were 160 clinical pregnancies in the aspirin (28.8{\%}) and 179 (31.9{\%}) in the placebo group [OR 0.86, 95{\%} CI (0.69-1.1)]. There were 129 ongoing pregnancies in the aspirin (23.6{\%}) and 147 in the placebo group (26.7{\%}) [OR 0.85, 95{\%} CI (0.65-1.1)]. Whereas the conventional meta-analysis limited to studies that could provide IPD showed an OR of 0.89 (95{\%} CI 0.69-1.2), the conventional meta-analysis limited to the eight studies of which method of randomization could be confirmed showed an OR of 0.94 (95{\%} CI 0.76-1.17) and the conventional meta-analysis including all 10 eligible RCTs identified with our search changed the OR to 1.07 (95{\%} CI 0.81-1.41). This difference in direction of effect, derived from the studies not able to share IPD of which quality of randomization could not be confirmed. Conclusions: Aspirin does not improve pregnancy rates after IVF.",
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Groeneveld, E, Broeze, KA, Lambers, MJ, Haapsamo, M, Dirckx, K, Schoot, BC, Salle, B, Duvan, CI, Schats, R, Mol, BW & Hompes, PGA 2011, 'Is aspirin effective in women undergoing in vitro fertilization (IVF)? Results from an individual patient data meta-analysis (IPD MA)', Human Reproduction Update, vol. 17, no. 4, dmr007, pp. 501-509. https://doi.org/10.1093/humupd/dmr007

Is aspirin effective in women undergoing in vitro fertilization (IVF)? Results from an individual patient data meta-analysis (IPD MA). / Groeneveld, E.; Broeze, K. A.; Lambers, M. J.; Haapsamo, M.; Dirckx, K.; Schoot, B. C.; Salle, B.; Duvan, C. I.; Schats, R.; Mol, B. W.; Hompes, P. G A.

In: Human Reproduction Update, Vol. 17, No. 4, dmr007, 01.07.2011, p. 501-509.

Research output: Contribution to journalArticle

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T1 - Is aspirin effective in women undergoing in vitro fertilization (IVF)? Results from an individual patient data meta-analysis (IPD MA)

AU - Groeneveld, E.

AU - Broeze, K. A.

AU - Lambers, M. J.

AU - Haapsamo, M.

AU - Dirckx, K.

AU - Schoot, B. C.

AU - Salle, B.

AU - Duvan, C. I.

AU - Schats, R.

AU - Mol, B. W.

AU - Hompes, P. G A

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N2 - Background: Aspirin is believed to improve the outcome of IVF, but previous conventional meta-analyses on the subject are conflicting. Therefore, we performed a meta-analysis with individual patient data (IPD MA) of randomized clinical trials (RCTs) on the subject. Methods: A systematic literature search was conducted to identify RCTs assessing the effectiveness of aspirin in IVF. Authors were asked to share their original data. In a one step meta-analytic approach, the treatment effect of aspirin was estimated with odds ratios (ORs) and 95% confidence intervals (CIs) using logistic regression, based on the intention to treat principle. Results: Ten studies fulfilled the inclusion criteria. Authors of six studies provided IPD, including 1119 patients (562 placebo and 557 aspirin). There were 160 clinical pregnancies in the aspirin (28.8%) and 179 (31.9%) in the placebo group [OR 0.86, 95% CI (0.69-1.1)]. There were 129 ongoing pregnancies in the aspirin (23.6%) and 147 in the placebo group (26.7%) [OR 0.85, 95% CI (0.65-1.1)]. Whereas the conventional meta-analysis limited to studies that could provide IPD showed an OR of 0.89 (95% CI 0.69-1.2), the conventional meta-analysis limited to the eight studies of which method of randomization could be confirmed showed an OR of 0.94 (95% CI 0.76-1.17) and the conventional meta-analysis including all 10 eligible RCTs identified with our search changed the OR to 1.07 (95% CI 0.81-1.41). This difference in direction of effect, derived from the studies not able to share IPD of which quality of randomization could not be confirmed. Conclusions: Aspirin does not improve pregnancy rates after IVF.

AB - Background: Aspirin is believed to improve the outcome of IVF, but previous conventional meta-analyses on the subject are conflicting. Therefore, we performed a meta-analysis with individual patient data (IPD MA) of randomized clinical trials (RCTs) on the subject. Methods: A systematic literature search was conducted to identify RCTs assessing the effectiveness of aspirin in IVF. Authors were asked to share their original data. In a one step meta-analytic approach, the treatment effect of aspirin was estimated with odds ratios (ORs) and 95% confidence intervals (CIs) using logistic regression, based on the intention to treat principle. Results: Ten studies fulfilled the inclusion criteria. Authors of six studies provided IPD, including 1119 patients (562 placebo and 557 aspirin). There were 160 clinical pregnancies in the aspirin (28.8%) and 179 (31.9%) in the placebo group [OR 0.86, 95% CI (0.69-1.1)]. There were 129 ongoing pregnancies in the aspirin (23.6%) and 147 in the placebo group (26.7%) [OR 0.85, 95% CI (0.65-1.1)]. Whereas the conventional meta-analysis limited to studies that could provide IPD showed an OR of 0.89 (95% CI 0.69-1.2), the conventional meta-analysis limited to the eight studies of which method of randomization could be confirmed showed an OR of 0.94 (95% CI 0.76-1.17) and the conventional meta-analysis including all 10 eligible RCTs identified with our search changed the OR to 1.07 (95% CI 0.81-1.41). This difference in direction of effect, derived from the studies not able to share IPD of which quality of randomization could not be confirmed. Conclusions: Aspirin does not improve pregnancy rates after IVF.

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KW - In vitro fertilization

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