Abstract
The purpose of this study was to examine the relationship between preterm birth and 22 single nucleotide polymorphisms in genes that encode cytokines and mediators of apoptosis and host defense. Two hundred two white women with a spontaneous preterm birth of <35 weeks of gestation were compared with 185 white women with term births. Genotyping was performed with polymerase chain reaction and sequence specific primers. Multivariable analyses included demographic and genetic variables. Alcohol (multivariable odds ratio, 2.3; P =. 001] and substance use (multivariable odds ratio, 3.7; P =. 01) were associated with preterm birth at <35 weeks of gestation. Smoking (multivariable odds ratio, 2.3; P =. 03), haplotypes IL10 -1082A/-819T/-592A (multivariable odds ratio, 2.1; P =. 04), tumor necrosis factor (TNF)+488A/-238G/-308G (multivariable odds ratio, 2.4; P =. 04), and IL4 -509C/C (multivariable odds ratio, 3.4; P =. 02), and the presence of MBL2 codon 54Asp (multivariable odds ratio, 2.3; P =. 02) were associated independently with preterm birth at <29 weeks of gestation. Homozygosity for IL10 -1082G/-819C/-592C haplotype (multivariable odds ratio, 1.9; P =. 02) was more common in women with preterm premature rupture of membranes. Polymorphisms in immunoregulatory genes may influence susceptibility to preterm birth or premature rupture of membranes.
| Language | English |
|---|---|
| Pages | 2056-2067 |
| Number of pages | 12 |
| Journal | American Journal of Obstetrics and Gynecology |
| Volume | 191 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 1 Dec 2004 |
| Externally published | Yes |
Keywords
- Cytokine
- Mannose-binding protein C
- Polymorphism
- Premature rupture of membranes
- Preterm birth
ASJC Scopus subject areas
- Obstetrics and Gynaecology
Cite this
}
Interleukins-1, -4, -6, -10, tumor necrosis factor, transforming growth factor-β, FAS, and mannose-binding protein C gene polymorphisms in Australian women : Risk of preterm birth. / Annells, Margaret F.; Hart, Prue H.; Mullighan, Charles G.; Heatley, Susan L.; Robinson, Jeffrey S.; Bardy, Peter; McDonald, Helen M.
In: American Journal of Obstetrics and Gynecology, Vol. 191, No. 6, 01.12.2004, p. 2056-2067.Research output: Contribution to journal › Article
TY - JOUR
T1 - Interleukins-1, -4, -6, -10, tumor necrosis factor, transforming growth factor-β, FAS, and mannose-binding protein C gene polymorphisms in Australian women
T2 - American journal of obstetrics and gynecology
AU - Annells, Margaret F.
AU - Hart, Prue H.
AU - Mullighan, Charles G.
AU - Heatley, Susan L.
AU - Robinson, Jeffrey S.
AU - Bardy, Peter
AU - McDonald, Helen M.
PY - 2004/12/1
Y1 - 2004/12/1
N2 - The purpose of this study was to examine the relationship between preterm birth and 22 single nucleotide polymorphisms in genes that encode cytokines and mediators of apoptosis and host defense. Two hundred two white women with a spontaneous preterm birth of <35 weeks of gestation were compared with 185 white women with term births. Genotyping was performed with polymerase chain reaction and sequence specific primers. Multivariable analyses included demographic and genetic variables. Alcohol (multivariable odds ratio, 2.3; P =. 001] and substance use (multivariable odds ratio, 3.7; P =. 01) were associated with preterm birth at <35 weeks of gestation. Smoking (multivariable odds ratio, 2.3; P =. 03), haplotypes IL10 -1082A/-819T/-592A (multivariable odds ratio, 2.1; P =. 04), tumor necrosis factor (TNF)+488A/-238G/-308G (multivariable odds ratio, 2.4; P =. 04), and IL4 -509C/C (multivariable odds ratio, 3.4; P =. 02), and the presence of MBL2 codon 54Asp (multivariable odds ratio, 2.3; P =. 02) were associated independently with preterm birth at <29 weeks of gestation. Homozygosity for IL10 -1082G/-819C/-592C haplotype (multivariable odds ratio, 1.9; P =. 02) was more common in women with preterm premature rupture of membranes. Polymorphisms in immunoregulatory genes may influence susceptibility to preterm birth or premature rupture of membranes.
AB - The purpose of this study was to examine the relationship between preterm birth and 22 single nucleotide polymorphisms in genes that encode cytokines and mediators of apoptosis and host defense. Two hundred two white women with a spontaneous preterm birth of <35 weeks of gestation were compared with 185 white women with term births. Genotyping was performed with polymerase chain reaction and sequence specific primers. Multivariable analyses included demographic and genetic variables. Alcohol (multivariable odds ratio, 2.3; P =. 001] and substance use (multivariable odds ratio, 3.7; P =. 01) were associated with preterm birth at <35 weeks of gestation. Smoking (multivariable odds ratio, 2.3; P =. 03), haplotypes IL10 -1082A/-819T/-592A (multivariable odds ratio, 2.1; P =. 04), tumor necrosis factor (TNF)+488A/-238G/-308G (multivariable odds ratio, 2.4; P =. 04), and IL4 -509C/C (multivariable odds ratio, 3.4; P =. 02), and the presence of MBL2 codon 54Asp (multivariable odds ratio, 2.3; P =. 02) were associated independently with preterm birth at <29 weeks of gestation. Homozygosity for IL10 -1082G/-819C/-592C haplotype (multivariable odds ratio, 1.9; P =. 02) was more common in women with preterm premature rupture of membranes. Polymorphisms in immunoregulatory genes may influence susceptibility to preterm birth or premature rupture of membranes.
KW - Cytokine
KW - Mannose-binding protein C
KW - Polymorphism
KW - Premature rupture of membranes
KW - Preterm birth
UR - http://www.scopus.com/inward/record.url?scp=10044292767&partnerID=8YFLogxK
U2 - 10.1016/j.ajog.2004.04.021
DO - 10.1016/j.ajog.2004.04.021
M3 - Article
VL - 191
SP - 2056
EP - 2067
JO - American journal of obstetrics and gynecology
JF - American journal of obstetrics and gynecology
SN - 0002-9378
IS - 6
ER -