Intake of vitamin D and risk of type 1 diabetes: A birth-cohort study

Elina Hyppönen, Esa Läärä, Antti Reunanen, Marjo Riitta Järvelin, Suvi M. Virtanen

    Research output: Contribution to journalArticle

    1386 Citations (Scopus)

    Abstract

    Background: Dietary vitamin D supplementation is associated with reduced risk of type 1 diabetes in animals. Our aim was to ascertain whether or not vitamin D supplementation or deficiency in infancy could affect development of type 1 diabetes. Methods: A birth-cohort study was done, in which all pregnant women (n=12 055) in Oulu and Lapland, northern Finland, who were due to give birth in 1966 were enrolled. Data was collected in the first year of life about frequency and dose of vitamin D supplementation and presence of suspected rickets. Our primary outcome measure was diagnosis of type 1 diabetes by end of December, 1997. Findings: 12 058 of 12 231 represented live births, and 10 821 (91% of those alive) children were followed-up at age 1 year. Of the 10 366 children included in analyses, 81 were diagnosed with diabetes during the study. Vitamin D supplementation was associated with a decreased frequency of type 1 diabetes when adjusted for neonatal, anthropometric, and social characteristics (rate ratio [RR] for regular vs no supplementation 0.12, 95% CI 0.03-0.51, and irregular vs no supplementation 0.16, 0.04-0.74. Children who regularly took the recommended dose of vitamin D (2000 IU daily) had a RR of 0.22 (0.05-0.89) compared with those who regularly received less than the recommended amount. Children suspected of having rickets during the first year of life had a RR of 3.0 (1.0-9.0) compared with those without such a suspicion. Interpretation: Dietary vitamin D supplementation is associated with reduced risk of type 1 diabetes. Ensuring adequate vitamin D supplementation for infants could help to reverse the increasing trend in the incidence of type 1 diabetes.

    LanguageEnglish
    Pages1500-1503
    Number of pages4
    JournalLancet
    Volume358
    Issue number9292
    DOIs
    Publication statusPublished - 3 Nov 2001

    ASJC Scopus subject areas

    • Medicine(all)

    Cite this

    Hyppönen, E., Läärä, E., Reunanen, A., Järvelin, M. R., & Virtanen, S. M. (2001). Intake of vitamin D and risk of type 1 diabetes: A birth-cohort study. Lancet, 358(9292), 1500-1503. https://doi.org/10.1016/S0140-6736(01)06580-1
    Hyppönen, Elina ; Läärä, Esa ; Reunanen, Antti ; Järvelin, Marjo Riitta ; Virtanen, Suvi M. / Intake of vitamin D and risk of type 1 diabetes : A birth-cohort study. In: Lancet. 2001 ; Vol. 358, No. 9292. pp. 1500-1503.
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    abstract = "Background: Dietary vitamin D supplementation is associated with reduced risk of type 1 diabetes in animals. Our aim was to ascertain whether or not vitamin D supplementation or deficiency in infancy could affect development of type 1 diabetes. Methods: A birth-cohort study was done, in which all pregnant women (n=12 055) in Oulu and Lapland, northern Finland, who were due to give birth in 1966 were enrolled. Data was collected in the first year of life about frequency and dose of vitamin D supplementation and presence of suspected rickets. Our primary outcome measure was diagnosis of type 1 diabetes by end of December, 1997. Findings: 12 058 of 12 231 represented live births, and 10 821 (91{\%} of those alive) children were followed-up at age 1 year. Of the 10 366 children included in analyses, 81 were diagnosed with diabetes during the study. Vitamin D supplementation was associated with a decreased frequency of type 1 diabetes when adjusted for neonatal, anthropometric, and social characteristics (rate ratio [RR] for regular vs no supplementation 0.12, 95{\%} CI 0.03-0.51, and irregular vs no supplementation 0.16, 0.04-0.74. Children who regularly took the recommended dose of vitamin D (2000 IU daily) had a RR of 0.22 (0.05-0.89) compared with those who regularly received less than the recommended amount. Children suspected of having rickets during the first year of life had a RR of 3.0 (1.0-9.0) compared with those without such a suspicion. Interpretation: Dietary vitamin D supplementation is associated with reduced risk of type 1 diabetes. Ensuring adequate vitamin D supplementation for infants could help to reverse the increasing trend in the incidence of type 1 diabetes.",
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    Hyppönen, E, Läärä, E, Reunanen, A, Järvelin, MR & Virtanen, SM 2001, 'Intake of vitamin D and risk of type 1 diabetes: A birth-cohort study', Lancet, vol. 358, no. 9292, pp. 1500-1503. https://doi.org/10.1016/S0140-6736(01)06580-1

    Intake of vitamin D and risk of type 1 diabetes : A birth-cohort study. / Hyppönen, Elina; Läärä, Esa; Reunanen, Antti; Järvelin, Marjo Riitta; Virtanen, Suvi M.

    In: Lancet, Vol. 358, No. 9292, 03.11.2001, p. 1500-1503.

    Research output: Contribution to journalArticle

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    AU - Hyppönen, Elina

    AU - Läärä, Esa

    AU - Reunanen, Antti

    AU - Järvelin, Marjo Riitta

    AU - Virtanen, Suvi M.

    PY - 2001/11/3

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    N2 - Background: Dietary vitamin D supplementation is associated with reduced risk of type 1 diabetes in animals. Our aim was to ascertain whether or not vitamin D supplementation or deficiency in infancy could affect development of type 1 diabetes. Methods: A birth-cohort study was done, in which all pregnant women (n=12 055) in Oulu and Lapland, northern Finland, who were due to give birth in 1966 were enrolled. Data was collected in the first year of life about frequency and dose of vitamin D supplementation and presence of suspected rickets. Our primary outcome measure was diagnosis of type 1 diabetes by end of December, 1997. Findings: 12 058 of 12 231 represented live births, and 10 821 (91% of those alive) children were followed-up at age 1 year. Of the 10 366 children included in analyses, 81 were diagnosed with diabetes during the study. Vitamin D supplementation was associated with a decreased frequency of type 1 diabetes when adjusted for neonatal, anthropometric, and social characteristics (rate ratio [RR] for regular vs no supplementation 0.12, 95% CI 0.03-0.51, and irregular vs no supplementation 0.16, 0.04-0.74. Children who regularly took the recommended dose of vitamin D (2000 IU daily) had a RR of 0.22 (0.05-0.89) compared with those who regularly received less than the recommended amount. Children suspected of having rickets during the first year of life had a RR of 3.0 (1.0-9.0) compared with those without such a suspicion. Interpretation: Dietary vitamin D supplementation is associated with reduced risk of type 1 diabetes. Ensuring adequate vitamin D supplementation for infants could help to reverse the increasing trend in the incidence of type 1 diabetes.

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    Hyppönen E, Läärä E, Reunanen A, Järvelin MR, Virtanen SM. Intake of vitamin D and risk of type 1 diabetes: A birth-cohort study. Lancet. 2001 Nov 3;358(9292):1500-1503. https://doi.org/10.1016/S0140-6736(01)06580-1