Insulin potentiating action of a peptide fraction from human urine

F. M. Ng, P. Z. Zimmet, G. Seiler, P. Taft, J. Bornstein

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

An impure peptide preparation from human urine was shown to have similar biological effects in vitro and in vivo to synthetic peptides containing the human growth hormone sequence Leu Ser Arg Leu Phe Asp Asn Ala (residues 6-13). The urinary preparation potentiates the action of insulin in the isolated rat diaphragm and in rabbits and rats, but the latter animals are far more sensitive to its action. Species specificity is possibly a significant factor in determining dosage in future studies.

LanguageEnglish
Pages950-956
Number of pages7
JournalDiabetes
Volume23
Issue number12
Publication statusPublished - 1974
Externally publishedYes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Ng, F. M., Zimmet, P. Z., Seiler, G., Taft, P., & Bornstein, J. (1974). Insulin potentiating action of a peptide fraction from human urine. Diabetes, 23(12), 950-956.
Ng, F. M. ; Zimmet, P. Z. ; Seiler, G. ; Taft, P. ; Bornstein, J. / Insulin potentiating action of a peptide fraction from human urine. In: Diabetes. 1974 ; Vol. 23, No. 12. pp. 950-956.
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Ng, FM, Zimmet, PZ, Seiler, G, Taft, P & Bornstein, J 1974, 'Insulin potentiating action of a peptide fraction from human urine', Diabetes, vol. 23, no. 12, pp. 950-956.

Insulin potentiating action of a peptide fraction from human urine. / Ng, F. M.; Zimmet, P. Z.; Seiler, G.; Taft, P.; Bornstein, J.

In: Diabetes, Vol. 23, No. 12, 1974, p. 950-956.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Insulin potentiating action of a peptide fraction from human urine

AU - Ng, F. M.

AU - Zimmet, P. Z.

AU - Seiler, G.

AU - Taft, P.

AU - Bornstein, J.

PY - 1974

Y1 - 1974

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VL - 23

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Ng FM, Zimmet PZ, Seiler G, Taft P, Bornstein J. Insulin potentiating action of a peptide fraction from human urine. Diabetes. 1974;23(12):950-956.