Infusional high-density lipoproteins therapies as a novel strategy for treating atherosclerosis

Belinda A. Di Bartolo, Nisha Schwarz, Jordan Andrews, Stephen J. Nicholls

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

High-density lipoproteins (HDL) have received considerable interest as a target for the development of novel anti-atherosclerotic agents beyond conventional approaches to lipid lowering. While a number of approaches have focused on modifying remodeling and expression pathways implicated in the regulation of HDL levels, an additional approach involves simply infusions of delipidated HDL. Several groups have advanced HDL infusions to clinical development with intriguing signs suggesting potentially favorable impacts at the level of the artery wall. The findings of early studies of infusional HDL therapies will be reviewed.

Original languageEnglish
Pages (from-to)210-214
Number of pages5
JournalArchives of Medical Science
Volume13
Issue number1
DOIs
Publication statusPublished - 1 Feb 2017

Keywords

  • Atherosclerosis
  • Clinical trials
  • High density lipoprotein
  • Imaging
  • Lipids
  • Risk factors

ASJC Scopus subject areas

  • Medicine(all)

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