Abstract
In this study, the influence of sample matrix on the relative bioavailability of arsenic (As), cadmium (Cd) and lead (Pb) was assessed following exposure of C57BL/6 mice to spiked aged (12 years) soils. AIN93G mouse chow was amended with individual and tertiary As, Cd and Pb soil combinations which were administered to mice over a 9 day exposure period. Contaminant relative bioavailability was calculated by comparing As urinary excretion and Cd-kidney/Pb-liver accumulation to corresponding values for compounds used to derive the respective toxicity reference value. Strong linear dose-responses were observed for mice exposed to AIN93G mouse chow augmented with individually spiked soil with As, Cd and Pb. When mice were exposed to co-contaminants, As relative bioavailability (RBA) decreased similar to results from previous co-contaminant salt experiments presumably due to the influence of Cd on phosphate transport proteins, which are utilized for As absorption. However, a decrease in Cd-kidney and Pb-liver accumulation was also observed following co-co-exposure. It was postulated that this resulted from interactions with other (essential) metals (e.g. iron, aluminium, manganese, magnesium) within the soil matrix and their influence on absorption via divalent metal transporters.
| Language | English |
|---|---|
| Pages | 660-665 |
| Number of pages | 6 |
| Journal | Science of the Total Environment |
| Volume | 595 |
| DOIs | |
| Publication status | Published - 1 Oct 2017 |
Keywords
- Arsenic
- Bioavailability
- Cadmium
- Co-exposure
- Lead
- Spiked-soil
ASJC Scopus subject areas
- Environmental Engineering
- Environmental Chemistry
- Waste Management and Disposal
- Pollution
Cite this
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Influence of sample matrix on the bioavailability of arsenic, cadmium and lead during co-contaminant exposure. / Ollson, Cameron J.; Smith, Euan; Herde, Paul; Juhasz, Albert L.
In: Science of the Total Environment, Vol. 595, 01.10.2017, p. 660-665.Research output: Contribution to journal › Article
TY - JOUR
T1 - Influence of sample matrix on the bioavailability of arsenic, cadmium and lead during co-contaminant exposure
AU - Ollson, Cameron J.
AU - Smith, Euan
AU - Herde, Paul
AU - Juhasz, Albert L.
PY - 2017/10/1
Y1 - 2017/10/1
N2 - In this study, the influence of sample matrix on the relative bioavailability of arsenic (As), cadmium (Cd) and lead (Pb) was assessed following exposure of C57BL/6 mice to spiked aged (12 years) soils. AIN93G mouse chow was amended with individual and tertiary As, Cd and Pb soil combinations which were administered to mice over a 9 day exposure period. Contaminant relative bioavailability was calculated by comparing As urinary excretion and Cd-kidney/Pb-liver accumulation to corresponding values for compounds used to derive the respective toxicity reference value. Strong linear dose-responses were observed for mice exposed to AIN93G mouse chow augmented with individually spiked soil with As, Cd and Pb. When mice were exposed to co-contaminants, As relative bioavailability (RBA) decreased similar to results from previous co-contaminant salt experiments presumably due to the influence of Cd on phosphate transport proteins, which are utilized for As absorption. However, a decrease in Cd-kidney and Pb-liver accumulation was also observed following co-co-exposure. It was postulated that this resulted from interactions with other (essential) metals (e.g. iron, aluminium, manganese, magnesium) within the soil matrix and their influence on absorption via divalent metal transporters.
AB - In this study, the influence of sample matrix on the relative bioavailability of arsenic (As), cadmium (Cd) and lead (Pb) was assessed following exposure of C57BL/6 mice to spiked aged (12 years) soils. AIN93G mouse chow was amended with individual and tertiary As, Cd and Pb soil combinations which were administered to mice over a 9 day exposure period. Contaminant relative bioavailability was calculated by comparing As urinary excretion and Cd-kidney/Pb-liver accumulation to corresponding values for compounds used to derive the respective toxicity reference value. Strong linear dose-responses were observed for mice exposed to AIN93G mouse chow augmented with individually spiked soil with As, Cd and Pb. When mice were exposed to co-contaminants, As relative bioavailability (RBA) decreased similar to results from previous co-contaminant salt experiments presumably due to the influence of Cd on phosphate transport proteins, which are utilized for As absorption. However, a decrease in Cd-kidney and Pb-liver accumulation was also observed following co-co-exposure. It was postulated that this resulted from interactions with other (essential) metals (e.g. iron, aluminium, manganese, magnesium) within the soil matrix and their influence on absorption via divalent metal transporters.
KW - Arsenic
KW - Bioavailability
KW - Cadmium
KW - Co-exposure
KW - Lead
KW - Spiked-soil
UR - http://www.scopus.com/inward/record.url?scp=85017207036&partnerID=8YFLogxK
U2 - 10.1016/j.scitotenv.2017.04.036
DO - 10.1016/j.scitotenv.2017.04.036
M3 - Article
VL - 595
SP - 660
EP - 665
JO - Science of the Total Environment
T2 - Science of the Total Environment
JF - Science of the Total Environment
SN - 0048-9697
ER -