Influence of 'feedback' signals on spatial integration in receptive fields of cat area 17 neurons

Chun Wang, Jin Yu Huang, Cedric Bardy, Thomas FitzGibbon, Bogdan Dreher

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

'Feedback' signals from mammalian extrastriate visual cortices are reported to exert primarily an excitatory influence on the classical receptive field (CRF) of neurons in the primary visual cortex (V1). However, given the much larger CRFs of neurons in extrastriate visual cortices it is not yet understood how feedback signals influence the spatial integration of visual signals by V1 neurons. To investigate this, we reversibly inactivated one of the 'form-processing' extrastriate visual cortices, the postero-temporal visual (PTV) cortex, and examined changes in responses of V1 neurons to drifting grating patches up to 28° in diameter. We found that during inactivation of PTV cortex the magnitude of the responses to CRF-confined stimuli and that to large stimuli inducing maximum suppression (i.e. minimum responses) was significantly reduced, while the spatial extent of the CRF remained largely unaffected. As a result, the relative strength of the surround suppression increased marginally. This effect was apparent in both simple and complex cells. It was also strong and consistent in cells located in supragranular and infragranular layers. For those cells exhibiting some relief from surround suppression or 'counter-suppression' when large stimuli patches were applied, the effect on counter-suppression was heterogeneous. Overall, the relative integrated responses to the 28° grating patches were also decreased when PTV cortex was inactivated. Thus, a substantial reduction in the CRF response and the largely unaffected spatial extent of the CRF as well as a weak surround effect observed in the present study are consistent with a multiplicative scaling effect.

Original languageEnglish
Pages (from-to)34-48
Number of pages15
JournalBrain Research
Volume1328
DOIs
Publication statusPublished or Issued - 30 Apr 2010
Externally publishedYes

Keywords

  • CRF response
  • Counter-suppression
  • Electrophysiology
  • Postero-temporal visual cortex
  • Reversible cortical inactivation
  • Single unit recording
  • Surround suppression
  • Vision

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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