Influence of clinical characteristics on maternal DHA and other polyunsaturated fatty acid status in pregnancy: A systematic review

N. A. Wilson, E. Mantzioris, P. F. Middleton, B. S. Muhlhausler

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Introduction: Omega-3 DHA is important for the prevention of preterm birth, however there is limited knowledge of the determinants of omega-3 status during pregnancy. The primary objective of this systematic review was to synthesise data from existing studies assessing relationships between clinical factors and maternal DHA status. Materials and methods: The Medline, Embase, Amed, and CINAHL databases were searched for studies reporting measures of maternal omega-3 status and one or more clinical characteristics. Results: Eighteen studies were included in the final analyses. Factors associated with a higher BMI (overweight, higher gestational weight gain, gestational diabetes), or lower parity were each associated with higher omega-3 status in the majority of studies, with mixed findings for other comparisons. Discussion: Inconsistent findings between studies make it difficult to draw clear conclusions about the relationship between clinical factors and maternal omega-3 DHA status. However, maternal overweight and associated metabolic conditions may increase lipid metabolism.

Original languageEnglish
Article number102063
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Publication statusPublished or Issued - Mar 2020


  • BMI
  • DHA
  • Maternal status
  • Omega-3
  • Omega-6
  • Polyunsaturated fatty acids

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology

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