Influence of α1and α2-adrenoceptor antagonist therapy on the development of hypertension in spontaneously hypertensive rats

Richard Young, Julie R. Jonsson, Mark T. Mano, Derek B. Frewin, Richard J. Head

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

There is general agreement that the sympathetic nervous system is involved in the development of hypertension in spontaneously hypertensive rats (SHR). However, in a previous study we established that chronic administration of the selective α1-adrenoceptor antagonist terazosin to SHR failed to prevent this phenomenon. In the present study, we extended that investigation further by examining the effects of another selective α1antagonist (doxazosin), an α2-adrenoceptor antagonist (yohimbine), and a combination of these agents. Chronic administration of doxazosin and yohimbine produced receptor blockade, as determined by their effect on blood pressure (BP) responses to norepinephrine (NE) and phenylephrine. Chronic administration of either antagonist alone or the two in combination failed to prevent the development of hypertension in SHR, however. These findings suggest that although there may be a need for involvement of the sympathetic nervous system in the development of hypertension in SHR, its influence on this process is not mediated through activation of α-adrenoceptors.

Original languageEnglish
Pages (from-to)780-790
Number of pages11
JournalJournal of Cardiovascular Pharmacology
Volume21
Issue number5
Publication statusPublished - 1 Jan 1993
Externally publishedYes

Keywords

  • Doxazosin
  • Hypertension
  • Spontaneously hypertensive rats
  • Yohimbine
  • α-Adrenoceptor antagonist

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

Cite this