Inflammation, plaque progression and vulnerability: evidence from intravascular ultrasound imaging.

Yu Kataoka, Rishi Puri, Stephen J Nicholls

Research output: Contribution to journalArticlepeer-review


Increasing evidence points to a critical role of inflammation in the development and propagation of atherosclerotic cardiovascular disease. Pathological studies in human and animal models have elucidated specific inflammatory mediators contributing to the progression and rupture of atherosclerotic plaque in the artery wall. These observations not only outline the importance of inflammation in atheroma progression but also the potential of anti-inflammatory therapeutic approaches to prevent and stabilize atherosclerotic disease. Intravascular ultrasonography enables direct atheroma visualization in vivo. Additionally, refinements in ultrasound technology permitting radiofrequency backscatter analysis enhance plaque characterization associated with disease instability. These imaging modalities will continue to provide opportunities for evaluating novel inflammatory mechanisms and anti-inflammatory therapies.
Original languageEnglish
Pages (from-to)280-9
Number of pages10
JournalCardiovascular Diagnosis and Therapy
Issue number4
Publication statusPublished or Issued - 2015


  • 05
  • 06
  • 10
  • 2015
  • 22
  • 2223-3652
  • 3978
  • accepted for publication apr
  • atherosclerosis
  • doi
  • imaging
  • inflammation
  • intravascular ultrasound
  • issn
  • ivus
  • j
  • plaque progression
  • plaque vulnerability
  • submitted mar 24

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