Induction of labour for improving birth outcomes for women at or beyond term

A. Metin Gülmezoglu, Caroline A. Crowther, Philippa Middleton

Research output: Contribution to journalReview articlepeer-review

75 Citations (Scopus)

Abstract

Background: As a pregnancy continues beyond termthe risks of babies dying inside the womb or in the immediate newborn period increase. Whether a policy of labour induction at a predetermined gestational age can reduce this increased risk is the subject of this review. Objectives: To evaluate the benefits and harms of a policy of labour induction at term or post-term compared to awaiting spontaneous labour or later induction of labour. Search strategy: We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (June 2006). We updated this search on 14 July 2009 and added the results to the awaiting classification section. Selection criteria: Randomized controlled trials conducted in women at or beyond term. The eligible trials were those comparing a policy of labour induction to a policy of awaiting spontaneous onset of labour. Trials comparing cervical ripening methods, membrane stripping/ sweeping or nipple stimulation without any commitment to delivery within a certain time were excluded. Data collection and analysis: Two review authors independently evaluated potentially eligible trials and extracted data.Outcomes are analysed in twomain categories: gestational age and cervix status. Main results: We included 19 trials reporting on 7984 women. A policy of labour induction at 41 completed weeks or beyond was associated with fewer (all-cause) perinatal deaths (1/2986 versus 9/2953; relative risk (RR) 0.30; 95% confidence interval (CI) 0.09 to 0.99). The risk difference is 0.00 (95% CI 0.01 to 0.00). If deaths due to congenital abnormality are excluded, no deaths remain in the labour induction group and seven deaths remain in the no-induction group. There was no evidence of a statistically significant difference in the risk of caesarean section (RR 0.92; 95% CI 0.76 to 1.12; RR 0.97; 95% CI 0.72 to 1.31) for women induced at 41 and 42 completed weeks respectively.Women induced at 37 to 40 completed weeks were more likely to have a caesarean section with expectant management than those in the labour induction group (RR 0.58; 95% CI 0.34 to 0.99). There were fewer babies with meconium aspiration syndrome (41+: RR 0.29; 95% CI 0.12 to 0.68, four trials, 1325 women; 42+: RR 0.66; 95% CI 0.24 to 1.81, two trials, 388 women). Authors' conclusions: A policy of labour induction after 41 completed weeks or later compared to awaiting spontaneous labour either indefinitely or at least one week is associated with fewer perinatal deaths. However, the absolute risk is extremely small. Women should be appropriately counselled on both the relative and absolute risks.

Original languageEnglish
Article numberCD004945
JournalCochrane Database of Systematic Reviews
Issue number4
DOIs
Publication statusPublished or Issued - 2009

Keywords

  • *Labor, induced [adverse effects]
  • *Pregnancy, prolonged
  • Cesarean section
  • Infant mortality
  • Infant, newborn
  • Randomized controlled trials as topic
  • Risk

ASJC Scopus subject areas

  • Pharmacology (medical)

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