Improving vaccines by incorporating immunological coadjuvants

Cara K. Fraser, Kerrilyn R. Diener, Michael P. Brown, John D. Hayball

Research output: Contribution to journalReview articlepeer-review

72 Citations (Scopus)

Abstract

While vaccination continues to be the most successful interventionist health policy to date, infectious disease remains a significant cause of death worldwide. A primary reason that vaccination is not able to generate effective immunity is a lack of appropriate adjuvants capable of initiating the desired immune response. Adjuvant combinations can potentially overcome this problem; however, the possible permutations to consider, which include the route and kinetics of vaccination, as well as combinations of adjuvants, are practically limitless. This review aims to summarize the current understanding of adjuvants and related immunological processes and how this knowledge can and has been applied to the strategic selection of adjuvant combinations as components of vaccines against human infectious disease.

Original languageEnglish
Pages (from-to)559-578
Number of pages20
JournalExpert Review of Vaccines
Volume6
Issue number4
DOIs
Publication statusPublished or Issued - 1 Aug 2007

Keywords

  • Adjuvants
  • Coadjuvants
  • Infectious disease
  • Vaccines

ASJC Scopus subject areas

  • Immunology
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery

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