Improved endothelial function following a 14-month resistance exercise training program in adults with type 2 diabetes

N. D. Cohen, D. W. Dunstan, C. Robinson, E. Vulikh, P. Z. Zimmet, J. E. Shaw

Research output: Contribution to journalArticlepeer-review

84 Citations (Scopus)


Objective: We examined the effect of a 14-month progressive resistance training (PRT) program on endothelial function in both a supervised training (Center) group and non-supervised training (Home) group of patients with type 2 diabetes. We studied 28 men and women with type 2 diabetes who participated in a 14-month PRT involving an initial 2-month supervised program and a 12-month maintenance program. Methods: Endothelial function testing was performed through laser doppler flow responses in the skin microcirculation to iontophoresis of acetylcholine (ACh) and sodium nitroprusside (NaNP) and doses of 4, 8 and 16 mC were used. Measurements of vascular response (VR), HbA1c, weight and blood pressure were performed at 0, 2 and 14 months. Results: VR to ACh and NaNP was significantly increased at 14 months compared with baseline in both the Center and Home groups. However, no between-group differences were observed. A significant correlation was observed between HbA1c and VR to ACh at baseline and 8 weeks using 8 mC dose of ACh. There was a strong correlation between HbA1c at baseline and VR at 14 months using all three doses of ACh (4 mC:r = -0.546, p = 0.003, 8 mC:r = -0.470, p = 0.002, 16 mC:r = -0.547, p = 0.006). Conclusions/interpretation: Endothelial function is improved following 14 months of PRT in type 2 diabetes both in a supervised and non-supervised program. Strong correlations with HbA1c including initial HbA1c levels suggest that glycemic control may be an important factor in long-term regulation of endothelial function.

Original languageEnglish
Pages (from-to)405-411
Number of pages7
JournalDiabetes Research and Clinical Practice
Issue number3
Publication statusPublished or Issued - Mar 2008
Externally publishedYes


  • Endothelium
  • Resistance training
  • Type 2 diabetes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this