Both linear and cyclic derivatives of the cyclic 12-amino-acid antimicrobial peptide bactenecin were designed based on optimization of amphipathicity and charge location. In general, increasing the number of positive charges at the N and C termini and adding an extra tryptophan residue in the loop not only increased the activities against both gram- positive and gram-negative bacteria but also broadened the antimicrobial spectrum.
|Number of pages||3|
|Journal||Antimicrobial Agents and Chemotherapy|
|Publication status||Published - 1 May 1999|
ASJC Scopus subject areas
- Pharmacology (medical)
- Infectious Diseases