Immunomodulatory cationic peptide therapeutics: A new paradigm in infection and immunity

Neeloffer Mookherjee, Leola N.Y. Chow, Robert Hancock

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Natural cationic host defence (antimicrobial) peptides are widely distributed gene encoded molecules with diverse structures. There are more than 1200 natural Host Defence Peptides (HDPs) described to date. Due to the multifunctional roles defined for such peptides there is a keen interest in the potential therapeutic applications of HDPs and their synthetic mimics, Antimicrobial peptides and Innate Defence Regulator (IDR) peptides. These peptides constitute two broad classes of potential therapeutics; (i) with direct antimicrobial and/or anti-biofilm activity, and (ii) with immune-modulating and/or anti-inflammatory activity. Exploiting the immunomodulatory functions of these peptides represents a new therapeutic approach for resolution of infections and inflammatory disorders.

Original languageEnglish
Title of host publicationSmall Wonders
Subtitle of host publicationPeptides for Disease Control
PublisherAmerican Chemical Society
Pages1-19
Number of pages19
ISBN (Print)9780841227484
DOIs
Publication statusPublished - 1 Jan 2012
Externally publishedYes

Publication series

NameACS Symposium Series
Volume1095
ISSN (Print)0097-6156
ISSN (Electronic)1947-5918

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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