IL7RA polymorphisms and chronic inflammatory arthropathies

Catherine King, I. Alloza, M. Rooney, K. Vandenbroeck

Research output: Contribution to journalShort survey

30 Citations (Scopus)

Abstract

The C allele of a single nucleotide polymorphism (SNP), rs6897932, located in the interleukin-7 receptor alpha chain (IL7RA) was recently found to be associated with multiple sclerosis and Type I diabetes. We analysed 13 SNPs in the IL7RA gene in a combined cohort of patients with chronic inflammatory arthropathies (rheumatoid arthritis and juvenile idiopathic arthritis; 368 patients and 532 unaffected subjects). No significant associations with disease were found with the exception of the non-synonymous SNP rs6897932. This SNP showed modest enrichment of the TT genotype in arthritic patients compared with controls [P = 0.02; OR 1.72 (95% CI 1.08-2.75)]. Our data are suggestive for a role of rs6897932 in predisposition to chronic inflammatory arthropathies.

Original languageEnglish
Pages (from-to)429-431
Number of pages3
JournalTissue Antigens
Volume74
Issue number5
DOIs
Publication statusPublished - 1 Nov 2009
Externally publishedYes

Keywords

  • Interleukin-7 receptor alpha subunit
  • Juvenile idiopathic arthritis
  • Rheumatoid arthritis
  • Single nucleotide polymorphism

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Genetics

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