IL-1 receptor type I gene expression in the amygdala of inflammatory susceptible Lewis and inflammatory resistant Fischer rats

Patrick Frost, Ruth M. Barrientos, Shinya Makino, Ma Li Wong, Esther M. Sternberg

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11 Citations (Scopus)


Lewis (LEW/N) and Fischer (F344/N) rats have different responses to inflammatory and behavioral stressors due to differences in hypothalamus-pituitary-adrenal (HPA) axis function. For example, LEW/N rats are more sensitive to restraint, inflammation and experimentally induced autoimmunity due to decreased HPA activity. The HPA axis response to peripheral inflammation is mediated, at least in part, by IL-1β and its receptor, IL-1 type I (IL-1RI). Here, we studied the distribution of IL-1RI mRNA in the brains of LEW/N and F344/N rats, and demonstrated that IL-1RI mRNA expression has significantly increased in the basolateral nucleus (BLA) of the amygdala of LEW/N rats. These findings suggest that strain-specific HPA axis responses may be mediated by extrahypothalamic pathways.

Original languageEnglish
Pages (from-to)32-39
Number of pages8
JournalJournal of Neuroimmunology
Issue number1-2
Publication statusPublished - 3 Dec 2001


  • Amygdala
  • Fischer rat
  • HPA axis
  • IL-1 receptor type I
  • Lewis rat

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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