IL-1 receptor type I gene expression in the amygdala of inflammatory susceptible Lewis and inflammatory resistant Fischer rats

Patrick Frost, Ruth M. Barrientos, Shinya Makino, Ma Li Wong, Esther M. Sternberg

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Lewis (LEW/N) and Fischer (F344/N) rats have different responses to inflammatory and behavioral stressors due to differences in hypothalamus-pituitary-adrenal (HPA) axis function. For example, LEW/N rats are more sensitive to restraint, inflammation and experimentally induced autoimmunity due to decreased HPA activity. The HPA axis response to peripheral inflammation is mediated, at least in part, by IL-1β and its receptor, IL-1 type I (IL-1RI). Here, we studied the distribution of IL-1RI mRNA in the brains of LEW/N and F344/N rats, and demonstrated that IL-1RI mRNA expression has significantly increased in the basolateral nucleus (BLA) of the amygdala of LEW/N rats. These findings suggest that strain-specific HPA axis responses may be mediated by extrahypothalamic pathways.

LanguageEnglish
Pages32-39
Number of pages8
JournalJournal of Neuroimmunology
Volume121
Issue number1-2
DOIs
Publication statusPublished - 3 Dec 2001

Keywords

  • Amygdala
  • Fischer rat
  • HPA axis
  • IL-1 receptor type I
  • Lewis rat

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

Cite this

Frost, Patrick ; Barrientos, Ruth M. ; Makino, Shinya ; Wong, Ma Li ; Sternberg, Esther M. / IL-1 receptor type I gene expression in the amygdala of inflammatory susceptible Lewis and inflammatory resistant Fischer rats. In: Journal of Neuroimmunology. 2001 ; Vol. 121, No. 1-2. pp. 32-39.
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abstract = "Lewis (LEW/N) and Fischer (F344/N) rats have different responses to inflammatory and behavioral stressors due to differences in hypothalamus-pituitary-adrenal (HPA) axis function. For example, LEW/N rats are more sensitive to restraint, inflammation and experimentally induced autoimmunity due to decreased HPA activity. The HPA axis response to peripheral inflammation is mediated, at least in part, by IL-1β and its receptor, IL-1 type I (IL-1RI). Here, we studied the distribution of IL-1RI mRNA in the brains of LEW/N and F344/N rats, and demonstrated that IL-1RI mRNA expression has significantly increased in the basolateral nucleus (BLA) of the amygdala of LEW/N rats. These findings suggest that strain-specific HPA axis responses may be mediated by extrahypothalamic pathways.",
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IL-1 receptor type I gene expression in the amygdala of inflammatory susceptible Lewis and inflammatory resistant Fischer rats. / Frost, Patrick; Barrientos, Ruth M.; Makino, Shinya; Wong, Ma Li; Sternberg, Esther M.

In: Journal of Neuroimmunology, Vol. 121, No. 1-2, 03.12.2001, p. 32-39.

Research output: Contribution to journalArticle

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