Identifying the ion channels responsible for signaling gastro-intestinal based pain

Stuart M. Brierley, Patrick A. Hughes, Andrea M. Harrington, Grigori Y. Rychkov, L. Ashley Blackshaw

Research output: Contribution to journalReview articlepeer-review

11 Citations (Scopus)

Abstract

We are normally unaware of the complex signalling events which continuously occur within our internal organs. Most of us only become cognisant when sensations of hunger, fullness, urgency or gas arise. However, for patients with organic and functional bowel disorders pain is an unpleasant and often debilitating reminder. Furthermore, chronic pain still represents a large unmet need for clinical treatment. Consequently, chronic pain has a considerable economic impact on health care systems and the afflicted individuals. In order to address this need we must understand how symptoms are generated within the gut, the molecular pathways responsible for generating these signals and how this process changes in disease states.

Original languageEnglish
Pages (from-to)2768-2798
Number of pages31
JournalPharmaceuticals
Volume3
Issue number9
DOIs
Publication statusPublished or Issued - 2010

Keywords

  • ASICs
  • TRPA1
  • TRPV1
  • TRPV4
  • Visceral pain

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmaceutical Science

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