Identification of hypothalamic transcripts upregulated by antidepressants

Ma Li Wong, Pooja Khatri, Julio Licinio, Anna Esposito, Philip W. Gold

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)


Identification of quantitative changes in gene expression that occur in the brain after antidepressant treatment can yield novel molecular markers that may be useful in the diagnosis and treatment of major depression. Using a modification of the differential display polymerase chain reaction, we describe the isolation of two transcripts that are differentially expressed in the brain after an 8-week course of antidepressant administration, compared to saline-treated control animals.

Original languageEnglish
Pages (from-to)275-279
Number of pages5
JournalBiochemical and Biophysical Research Communications
Issue number1
Publication statusPublished or Issued - 4 Dec 1996

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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