Identification of hypothalamic transcripts upregulated by antidepressants

Ma Li Wong; Pooja Khatri; Julio Licinio; Anna Esposito; Philip W. Gold

doi:10.1006/bbrc.1996.1792

Identification of hypothalamic transcripts upregulated by antidepressants

Ma Li Wong, Pooja Khatri, Julio Licinio, Anna Esposito, Philip W. Gold

Lifelong Health

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Identification of quantitative changes in gene expression that occur in the brain after antidepressant treatment can yield novel molecular markers that may be useful in the diagnosis and treatment of major depression. Using a modification of the differential display polymerase chain reaction, we describe the isolation of two transcripts that are differentially expressed in the brain after an 8-week course of antidepressant administration, compared to saline-treated control animals.

Original language	English
Pages (from-to)	275-279
Number of pages	5
Journal	Biochemical and Biophysical Research Communications
Volume	229
Issue number	1
DOIs	https://doi.org/10.1006/bbrc.1996.1792
Publication status	Published or Issued - 4 Dec 1996

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1006/bbrc.1996.1792

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Cite this

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title = "Identification of hypothalamic transcripts upregulated by antidepressants",

abstract = "Identification of quantitative changes in gene expression that occur in the brain after antidepressant treatment can yield novel molecular markers that may be useful in the diagnosis and treatment of major depression. Using a modification of the differential display polymerase chain reaction, we describe the isolation of two transcripts that are differentially expressed in the brain after an 8-week course of antidepressant administration, compared to saline-treated control animals.",

author = "Wong, {Ma Li} and Pooja Khatri and Julio Licinio and Anna Esposito and Gold, {Philip W.}",

note = "Funding Information: We thank Sam Listwak (Clinical Neuroendocrinology Branch, National Institutes of Mental Health) for helping with sequencing gels and Margaret Levin (McConnel Lab, Department of Biological Sciences, Stanford University) for her helpful comments. This work was supported by a NARSAD (National Alliance for Research on Schizophrenia and Depression) Young Investigator Award to M.-L.W.",

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AU - Khatri, Pooja

AU - Licinio, Julio

AU - Esposito, Anna

AU - Gold, Philip W.

N1 - Funding Information: We thank Sam Listwak (Clinical Neuroendocrinology Branch, National Institutes of Mental Health) for helping with sequencing gels and Margaret Levin (McConnel Lab, Department of Biological Sciences, Stanford University) for her helpful comments. This work was supported by a NARSAD (National Alliance for Research on Schizophrenia and Depression) Young Investigator Award to M.-L.W.

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AB - Identification of quantitative changes in gene expression that occur in the brain after antidepressant treatment can yield novel molecular markers that may be useful in the diagnosis and treatment of major depression. Using a modification of the differential display polymerase chain reaction, we describe the isolation of two transcripts that are differentially expressed in the brain after an 8-week course of antidepressant administration, compared to saline-treated control animals.

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