Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion

Padraic G. Fallon, Sarah J. Ballantyne, Niamh E. Mangan, Jillian L. Barlow, Ayan Dasvarma, Duncan R. Hewett, Ann McIlgorm, Helen E. Jolin, Andrew N.J. McKenzie

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526 Citations (Scopus)

Abstract

Type 2 immunity, which involves coordinated regulation of innate and adaptive immune responses, can protect against helminth parasite infection, but may lead to allergy and asthma after inappropriate activation. We demonstrate that il25-/- mice display inefficient Nippostrongylus brasiliensis expulsion and delayed cytokine production by T helper 2 cells. We further establish a key role for interleukin (IL)-25 in regulating a novel population of IL-4-, IL-5-, IL-13-producing non-B/non-T (NBNT), c-kit+, Fcε R1- cells during helminth infection. A deficit in this population in il25-/- mice correlates with inefficient N. brasiliensis expulsion. In contrast, administration of recombinant IL-25 in vivo induces the appearance of NBNT, c-kit+, FcεR1- cells and leads to rapid worm expulsion that is T and B cell independent, but type 2 cytokine dependent. We demonstrate that these IL-25-regulated cells appear rapidly in the draining lymph nodes, implicating them as a source of type 2 cytokines during initiation of worm expulsion.

Original languageEnglish
Pages (from-to)1105-1116
Number of pages12
JournalJournal of Experimental Medicine
Volume203
Issue number4
DOIs
Publication statusPublished or Issued - 17 Apr 2006

ASJC Scopus subject areas

  • Medicine(all)

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