Human gastrointestinal neoplasia-associated myofibroblasts can develop from bone marrow-derived cells following allogeneic stem cell transplantation

Daniel L. Worthley, Andrew Ruszkiewicz, Ruth Davies, Sarah Moore, Ian Nivison-Smith, L. Bik To, Peter Browett, Robyn Western, Simon Durrant, Jason So, Graeme P. Young, Charles G. Mullighan, Peter G. Bardy, Michael Z. Michael

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Abstract

This study characterized the contribution of bone marrow-derived cells to human neoplasia and the perineoplastic stroma. The Australasian Bone Marrow Transplant Recipient Registry was used to identify solid organ neoplasia that developed in female recipients of male allogeneic stem cell transplants. Eighteen suitable cases were identified including several skin cancers, two gastric cancers, and one rectal adenoma. Light microscopy, fluorescence and chromogenic in situ hybridization, and immunohistochemistry were performed to determine the nature and origin of the neoplastic and stromal cells. In contrast to recent reports, donor-derived neoplastic cells were not detected. Bone marrow-derived neoplasia-associated myofibroblasts, however, were identified in the rectal adenoma and in a gastric cancer. Bone marrow-derived cells can generate myofibroblasts in the setting of human gastrointestinal neoplasia.

Original languageEnglish
Pages (from-to)1463-1468
Number of pages6
JournalStem Cells
Volume27
Issue number6
DOIs
Publication statusPublished - 1 Jun 2009

Keywords

  • Bone marrow transplantation
  • Cancer
  • Fibroblasts
  • Gastrointestinal neoplasms
  • Stromal cells

ASJC Scopus subject areas

  • Molecular Medicine
  • Developmental Biology
  • Cell Biology

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