The human lysosomal storage disorder fucosidosis results from the deficiency of α-L-fucosidase, a lysosomal enzyme essential for the catabolism of oligosaccharides containing α-L-fucosides. cDNA clones coding for human α-L-fucosidase have been isolated from λgt10 and λgtll cDNA libraries derived from human liver, placenta and colon. Compilation of cDNA sequences results in a nucleotide sequence of 2053 base pairs encoding α-L-fucosidase. The sequence contains an open reading frame of 461 amino acids beginning with the first in-frame methionine and includes 439 amino acids which comprise the mature protein in addition to a hydrophobic signal peptide sequence of 22 amino acids.
|Number of pages||7|
|Journal||Biochemical and Biophysical Research Communications|
|Publication status||Published or Issued - 16 Oct 1989|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology