TY - JOUR
T1 - HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24
AU - Kennedy, M. A.
AU - Gonzalez-Sarmiento, R.
AU - Kees, U. R.
AU - Lampert, F.
AU - Dear, N.
AU - Boehm, T.
AU - Rabbitts, T. H.
PY - 1991/1/1
Y1 - 1991/1/1
N2 - A common chromosomal abnormality in childhood T-cell acute leukemia is a translocation, t(10;14)(q24;q11), that together with the variant t(7;10)(q35;q24) is present in up to 7% of this tumor type. The gene adjacent to the 10q24 region is transcriptionally activated after translocation to either TCRD (14q11) or TCRB (7q35). It encodes a homeobox gene closely related to the developmentally regulated homeotic genes of flies and mammals. The coding capacity of this activated gene, designated HOX11, is undisturbed in a T-cell line carrying the translocation t(7;10)(q35;q24). Therefore, the HOX11 homeobox gene seems to be involved in T-cell tumorigenesis.
AB - A common chromosomal abnormality in childhood T-cell acute leukemia is a translocation, t(10;14)(q24;q11), that together with the variant t(7;10)(q35;q24) is present in up to 7% of this tumor type. The gene adjacent to the 10q24 region is transcriptionally activated after translocation to either TCRD (14q11) or TCRB (7q35). It encodes a homeobox gene closely related to the developmentally regulated homeotic genes of flies and mammals. The coding capacity of this activated gene, designated HOX11, is undisturbed in a T-cell line carrying the translocation t(7;10)(q35;q24). Therefore, the HOX11 homeobox gene seems to be involved in T-cell tumorigenesis.
KW - T-cell leukemia
KW - chromosomal translocation t(7;10)
UR - http://www.scopus.com/inward/record.url?scp=0026046616&partnerID=8YFLogxK
U2 - 10.1073/pnas.88.20.8900
DO - 10.1073/pnas.88.20.8900
M3 - Article
C2 - 1681546
AN - SCOPUS:0026046616
VL - 88
SP - 8900
EP - 8904
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 20
ER -