HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24

M. A. Kennedy, R. Gonzalez-Sarmiento, U. R. Kees, F. Lampert, N. Dear, T. Boehm, T. H. Rabbitts

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234 Citations (Scopus)

Abstract

A common chromosomal abnormality in childhood T-cell acute leukemia is a translocation, t(10;14)(q24;q11), that together with the variant t(7;10)(q35;q24) is present in up to 7% of this tumor type. The gene adjacent to the 10q24 region is transcriptionally activated after translocation to either TCRD (14q11) or TCRB (7q35). It encodes a homeobox gene closely related to the developmentally regulated homeotic genes of flies and mammals. The coding capacity of this activated gene, designated HOX11, is undisturbed in a T-cell line carrying the translocation t(7;10)(q35;q24). Therefore, the HOX11 homeobox gene seems to be involved in T-cell tumorigenesis.

Original languageEnglish
Pages (from-to)8900-8904
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume88
Issue number20
DOIs
Publication statusPublished - 1 Jan 1991

Keywords

  • T-cell leukemia
  • chromosomal translocation t(7;10)

ASJC Scopus subject areas

  • General

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