HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24

M. A. Kennedy; R. Gonzalez-Sarmiento; U. R. Kees; F. Lampert; N. Dear; T. Boehm; T. H. Rabbitts

doi:10.1073/pnas.88.20.8900

HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24

M. A. Kennedy, R. Gonzalez-Sarmiento, U. R. Kees, F. Lampert, N. Dear, T. Boehm, T. H. Rabbitts

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Abstract

A common chromosomal abnormality in childhood T-cell acute leukemia is a translocation, t(10;14)(q24;q11), that together with the variant t(7;10)(q35;q24) is present in up to 7% of this tumor type. The gene adjacent to the 10q24 region is transcriptionally activated after translocation to either TCRD (14q11) or TCRB (7q35). It encodes a homeobox gene closely related to the developmentally regulated homeotic genes of flies and mammals. The coding capacity of this activated gene, designated HOX11, is undisturbed in a T-cell line carrying the translocation t(7;10)(q35;q24). Therefore, the HOX11 homeobox gene seems to be involved in T-cell tumorigenesis.

Original language	English
Pages (from-to)	8900-8904
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	88
Issue number	20
DOIs	https://doi.org/10.1073/pnas.88.20.8900
Publication status	Published or Issued - 1991

Keywords

T-cell leukemia
chromosomal translocation t(7;10)

ASJC Scopus subject areas

General

Access to Document

10.1073/pnas.88.20.8900

Link to publication in Scopus

Cite this

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title = "HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24",

abstract = "A common chromosomal abnormality in childhood T-cell acute leukemia is a translocation, t(10;14)(q24;q11), that together with the variant t(7;10)(q35;q24) is present in up to 7% of this tumor type. The gene adjacent to the 10q24 region is transcriptionally activated after translocation to either TCRD (14q11) or TCRB (7q35). It encodes a homeobox gene closely related to the developmentally regulated homeotic genes of flies and mammals. The coding capacity of this activated gene, designated HOX11, is undisturbed in a T-cell line carrying the translocation t(7;10)(q35;q24). Therefore, the HOX11 homeobox gene seems to be involved in T-cell tumorigenesis.",

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T1 - HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24

AU - Kennedy, M. A.

AU - Gonzalez-Sarmiento, R.

AU - Kees, U. R.

AU - Lampert, F.

AU - Dear, N.

AU - Boehm, T.

AU - Rabbitts, T. H.

PY - 1991

Y1 - 1991

N2 - A common chromosomal abnormality in childhood T-cell acute leukemia is a translocation, t(10;14)(q24;q11), that together with the variant t(7;10)(q35;q24) is present in up to 7% of this tumor type. The gene adjacent to the 10q24 region is transcriptionally activated after translocation to either TCRD (14q11) or TCRB (7q35). It encodes a homeobox gene closely related to the developmentally regulated homeotic genes of flies and mammals. The coding capacity of this activated gene, designated HOX11, is undisturbed in a T-cell line carrying the translocation t(7;10)(q35;q24). Therefore, the HOX11 homeobox gene seems to be involved in T-cell tumorigenesis.

AB - A common chromosomal abnormality in childhood T-cell acute leukemia is a translocation, t(10;14)(q24;q11), that together with the variant t(7;10)(q35;q24) is present in up to 7% of this tumor type. The gene adjacent to the 10q24 region is transcriptionally activated after translocation to either TCRD (14q11) or TCRB (7q35). It encodes a homeobox gene closely related to the developmentally regulated homeotic genes of flies and mammals. The coding capacity of this activated gene, designated HOX11, is undisturbed in a T-cell line carrying the translocation t(7;10)(q35;q24). Therefore, the HOX11 homeobox gene seems to be involved in T-cell tumorigenesis.

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KW - chromosomal translocation t(7;10)

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