Host defense peptides and their advancements in translational Staphylococcus aureus research

Sarah C. Mansour, Robert Hancock

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Staphylococcus aureus is responsible for a multitude of infections ranging from skin and soft tissue infections to more severe invasive diseases. In response to S. aureus, host defense peptides (HDPs) are produced as nature’s own sentinel effector molecules. HDPs are small, often cationic, molecules that possess numerous biological activities, such as antimicrobial activity, cellular recruitment, anti-inflammatory properties, and wound healing, all of which play a role in controlling S. aureus infections. In hopes of capitalizing on the powerful anti-infective functions of HDPs, there has been a considerable amount of interest in deriving HDP-based therapeutics. Here, we highlight current advancements in HDP research, constraints to commercial development, and solutions for safer and more feasible HDP-based therapies against S. aureus.

LanguageEnglish
Title of host publicationHost Defense Peptides and Their Potential as Therapeutic Agents
PublisherSpringer International Publishing
Pages301-321
Number of pages21
ISBN (Electronic)9783319329499
ISBN (Print)9783319329475
DOIs
Publication statusPublished - 1 Jan 2016
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)
  • Immunology and Microbiology(all)

Cite this

Mansour, S. C., & Hancock, R. (2016). Host defense peptides and their advancements in translational Staphylococcus aureus research. In Host Defense Peptides and Their Potential as Therapeutic Agents (pp. 301-321). Springer International Publishing. https://doi.org/10.1007/978-3-319-32949-9_12