Host defence peptides from invertebrates - emerging antimicrobial strategies

Robert E.W. Hancock, Kelly L. Brown, Neeloffer Mookherjee

Research output: Contribution to journalReview articlepeer-review

196 Citations (Scopus)

Abstract

Cationic antimicrobial (host defence) peptides are found as potent components of the innate immune system of all invertebrates in which they have been investigated. They vary substantially in their amino acid sequences, secondary structures, inducibility, potency and antimicrobial activity spectra. This enormous diversity is providing templates for the design and development of both antibiotic peptides and peptides that selectively modulate innate immunity to increase protection against infections and sepsis.

Original languageEnglish
Pages (from-to)315-322
Number of pages8
JournalImmunobiology
Volume211
Issue number4
DOIs
Publication statusPublished or Issued - 2 Jun 2006
Externally publishedYes

Keywords

  • Antibiotics
  • Antimicrobial peptides
  • Cationic peptides
  • Innate immunity
  • Invertebrate immunity

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Hematology

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