Homocysteinemia after hypertensive pregnancy disorders at term

Sanne Visser, Wietske Hermes, Henk J. Blom, Annemieke C. Heijboer, Arie Franx, Maria G. Van Pampus, Kitty W M Bloemenkamp, Corine Koopmans, Ben Willem J Mol, Christianne J M De Groot

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Results from a number of long-term follow-up studies have suggested that hypertensive disorders in pregnancy are associated with increased risk of cardiovascular disease later in life. More recently, this putative relationship has been substantiated with findings of elevated cardiovascular risk factors, such as lipid profiles and glucose, in women with a history of hypertensive pregnancy disorders. Homocysteine is a sensitive indicator of increased risk but data on homocysteine levels in women with a history of hypertensive pregnancy disorders are inconsistent. Design: This cohort study included 279 women with a history of hypertensive pregnancy disorders at term and 85 women with a history of uncomplicated pregnancies who participated in the Hypitat Risk Assessment Study (HyRAS). Methods: Blood samples for total homocysteine determination were taken 2.5 years postpartum. Homocysteine levels were determined in plasma using an immunoassay. Results: Women with a history of hypertensive pregnancy disorders had significant higher median homocysteine levels (10.66μmol/L) 2.5 years postpartum compared with women with a history uncomplicated pregnancies (9.82μmol/L; p=0.002). Women with a history of hypertensive pregnancy disorders had a higher risk of having a homocysteine level in the highest quartile (odds ratio 3.4, 95% confidence interval 1.5-7.6). Conclusion: At 2.5 years postpartum, women with a history hypertensive pregnancy disorders had higher homocysteine levels than women who had uncomplicated pregnancies. Although higher homocysteine levels might be a potential link between a history of hypertensive pregnancy disorders and increased cardiovascular disease risk later in life, the clinical implications remain an area for future research.

LanguageEnglish
Pages524-529
Number of pages6
JournalJournal of Women's Health
Volume24
Issue number6
DOIs
Publication statusPublished - 1 Jun 2015

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Visser, S., Hermes, W., Blom, H. J., Heijboer, A. C., Franx, A., Van Pampus, M. G., ... De Groot, C. J. M. (2015). Homocysteinemia after hypertensive pregnancy disorders at term. Journal of Women's Health, 24(6), 524-529. https://doi.org/10.1089/jwh.2015.5201
Visser, Sanne ; Hermes, Wietske ; Blom, Henk J. ; Heijboer, Annemieke C. ; Franx, Arie ; Van Pampus, Maria G. ; Bloemenkamp, Kitty W M ; Koopmans, Corine ; Mol, Ben Willem J ; De Groot, Christianne J M. / Homocysteinemia after hypertensive pregnancy disorders at term. In: Journal of Women's Health. 2015 ; Vol. 24, No. 6. pp. 524-529.
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abstract = "Background: Results from a number of long-term follow-up studies have suggested that hypertensive disorders in pregnancy are associated with increased risk of cardiovascular disease later in life. More recently, this putative relationship has been substantiated with findings of elevated cardiovascular risk factors, such as lipid profiles and glucose, in women with a history of hypertensive pregnancy disorders. Homocysteine is a sensitive indicator of increased risk but data on homocysteine levels in women with a history of hypertensive pregnancy disorders are inconsistent. Design: This cohort study included 279 women with a history of hypertensive pregnancy disorders at term and 85 women with a history of uncomplicated pregnancies who participated in the Hypitat Risk Assessment Study (HyRAS). Methods: Blood samples for total homocysteine determination were taken 2.5 years postpartum. Homocysteine levels were determined in plasma using an immunoassay. Results: Women with a history of hypertensive pregnancy disorders had significant higher median homocysteine levels (10.66μmol/L) 2.5 years postpartum compared with women with a history uncomplicated pregnancies (9.82μmol/L; p=0.002). Women with a history of hypertensive pregnancy disorders had a higher risk of having a homocysteine level in the highest quartile (odds ratio 3.4, 95{\%} confidence interval 1.5-7.6). Conclusion: At 2.5 years postpartum, women with a history hypertensive pregnancy disorders had higher homocysteine levels than women who had uncomplicated pregnancies. Although higher homocysteine levels might be a potential link between a history of hypertensive pregnancy disorders and increased cardiovascular disease risk later in life, the clinical implications remain an area for future research.",
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Visser, S, Hermes, W, Blom, HJ, Heijboer, AC, Franx, A, Van Pampus, MG, Bloemenkamp, KWM, Koopmans, C, Mol, BWJ & De Groot, CJM 2015, 'Homocysteinemia after hypertensive pregnancy disorders at term', Journal of Women's Health, vol. 24, no. 6, pp. 524-529. https://doi.org/10.1089/jwh.2015.5201

Homocysteinemia after hypertensive pregnancy disorders at term. / Visser, Sanne; Hermes, Wietske; Blom, Henk J.; Heijboer, Annemieke C.; Franx, Arie; Van Pampus, Maria G.; Bloemenkamp, Kitty W M; Koopmans, Corine; Mol, Ben Willem J; De Groot, Christianne J M.

In: Journal of Women's Health, Vol. 24, No. 6, 01.06.2015, p. 524-529.

Research output: Contribution to journalArticle

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T1 - Homocysteinemia after hypertensive pregnancy disorders at term

AU - Visser, Sanne

AU - Hermes, Wietske

AU - Blom, Henk J.

AU - Heijboer, Annemieke C.

AU - Franx, Arie

AU - Van Pampus, Maria G.

AU - Bloemenkamp, Kitty W M

AU - Koopmans, Corine

AU - Mol, Ben Willem J

AU - De Groot, Christianne J M

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N2 - Background: Results from a number of long-term follow-up studies have suggested that hypertensive disorders in pregnancy are associated with increased risk of cardiovascular disease later in life. More recently, this putative relationship has been substantiated with findings of elevated cardiovascular risk factors, such as lipid profiles and glucose, in women with a history of hypertensive pregnancy disorders. Homocysteine is a sensitive indicator of increased risk but data on homocysteine levels in women with a history of hypertensive pregnancy disorders are inconsistent. Design: This cohort study included 279 women with a history of hypertensive pregnancy disorders at term and 85 women with a history of uncomplicated pregnancies who participated in the Hypitat Risk Assessment Study (HyRAS). Methods: Blood samples for total homocysteine determination were taken 2.5 years postpartum. Homocysteine levels were determined in plasma using an immunoassay. Results: Women with a history of hypertensive pregnancy disorders had significant higher median homocysteine levels (10.66μmol/L) 2.5 years postpartum compared with women with a history uncomplicated pregnancies (9.82μmol/L; p=0.002). Women with a history of hypertensive pregnancy disorders had a higher risk of having a homocysteine level in the highest quartile (odds ratio 3.4, 95% confidence interval 1.5-7.6). Conclusion: At 2.5 years postpartum, women with a history hypertensive pregnancy disorders had higher homocysteine levels than women who had uncomplicated pregnancies. Although higher homocysteine levels might be a potential link between a history of hypertensive pregnancy disorders and increased cardiovascular disease risk later in life, the clinical implications remain an area for future research.

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Visser S, Hermes W, Blom HJ, Heijboer AC, Franx A, Van Pampus MG et al. Homocysteinemia after hypertensive pregnancy disorders at term. Journal of Women's Health. 2015 Jun 1;24(6):524-529. https://doi.org/10.1089/jwh.2015.5201