HNF1A variant, energy-reduced diets and insulin resistance improvement during weight loss: The POUNDS Lost trial and DIRECT

Tao Huang, Tiange Wang, Yoriko Heianza, Dianjianyi Sun, Kerry Ivey, Ronen Durst, Dan Schwarzfuchs, Meir J. Stampfer, George A. Bray, Frank M. Sacks, Iris Shai, Lu Qi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Aim: To determine whether weight-loss diets varying in macronutrients modulate the genetic effect of hepatocyte nuclear factor 1α (HNF1A) rs7957197 on weight loss and improvement of insulin resistance. Materials and methods: We analysed the interaction between HNF1A rs7957197 and weight-loss diets with regard to weight loss and insulin resistance improvement among 722 overweight/obese adults from a 2-year randomized weight-loss trial, the POUNDS Lost trial. The findings were replicated in another independent 2-year weight-loss trial, the Dietary Intervention Randomized Controlled Trial (DIRECT), in 280 overweight/obese adults. Results: In the POUNDS Lost trial, we found that a high-fat diet significantly modified the genetic effect of HNF1A on weight loss and reduction in waist circumference (P for interaction =.006 and.005, respectively). Borderline significant interactions for fasting insulin and insulin resistance (P for interaction =.07 and.06, respectively) were observed. We replicated the results in DIRECT. Pooled results showed similar significant interactions with weight loss, waist circumference reduction, and improvement in fasting insulin and insulin resistance (P values for interaction =.001,.005,.02 and.03, respectively). Greater decreases in weight, waist circumference, fasting insulin level and insulin resistance were observed in participants with the T allele compared to those without the T allele in the high-fat diet group (P =.04,.03 and.01, respectively). Conclusions: Our replicable findings provide strong evidence that individuals with the HNF1A rs7957197 T allele might obtain more benefits in weight loss and improvement of insulin resistance by choosing a hypocaloric and high-fat diet.

LanguageEnglish
Pages1445-1452
Number of pages8
JournalDiabetes, Obesity and Metabolism
Volume20
Issue number6
DOIs
Publication statusPublished - 1 Jun 2018

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Huang, Tao ; Wang, Tiange ; Heianza, Yoriko ; Sun, Dianjianyi ; Ivey, Kerry ; Durst, Ronen ; Schwarzfuchs, Dan ; Stampfer, Meir J. ; Bray, George A. ; Sacks, Frank M. ; Shai, Iris ; Qi, Lu. / HNF1A variant, energy-reduced diets and insulin resistance improvement during weight loss : The POUNDS Lost trial and DIRECT. In: Diabetes, Obesity and Metabolism. 2018 ; Vol. 20, No. 6. pp. 1445-1452.
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abstract = "Aim: To determine whether weight-loss diets varying in macronutrients modulate the genetic effect of hepatocyte nuclear factor 1α (HNF1A) rs7957197 on weight loss and improvement of insulin resistance. Materials and methods: We analysed the interaction between HNF1A rs7957197 and weight-loss diets with regard to weight loss and insulin resistance improvement among 722 overweight/obese adults from a 2-year randomized weight-loss trial, the POUNDS Lost trial. The findings were replicated in another independent 2-year weight-loss trial, the Dietary Intervention Randomized Controlled Trial (DIRECT), in 280 overweight/obese adults. Results: In the POUNDS Lost trial, we found that a high-fat diet significantly modified the genetic effect of HNF1A on weight loss and reduction in waist circumference (P for interaction =.006 and.005, respectively). Borderline significant interactions for fasting insulin and insulin resistance (P for interaction =.07 and.06, respectively) were observed. We replicated the results in DIRECT. Pooled results showed similar significant interactions with weight loss, waist circumference reduction, and improvement in fasting insulin and insulin resistance (P values for interaction =.001,.005,.02 and.03, respectively). Greater decreases in weight, waist circumference, fasting insulin level and insulin resistance were observed in participants with the T allele compared to those without the T allele in the high-fat diet group (P =.04,.03 and.01, respectively). Conclusions: Our replicable findings provide strong evidence that individuals with the HNF1A rs7957197 T allele might obtain more benefits in weight loss and improvement of insulin resistance by choosing a hypocaloric and high-fat diet.",
author = "Tao Huang and Tiange Wang and Yoriko Heianza and Dianjianyi Sun and Kerry Ivey and Ronen Durst and Dan Schwarzfuchs and Stampfer, {Meir J.} and Bray, {George A.} and Sacks, {Frank M.} and Iris Shai and Lu Qi",
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Huang, T, Wang, T, Heianza, Y, Sun, D, Ivey, K, Durst, R, Schwarzfuchs, D, Stampfer, MJ, Bray, GA, Sacks, FM, Shai, I & Qi, L 2018, 'HNF1A variant, energy-reduced diets and insulin resistance improvement during weight loss: The POUNDS Lost trial and DIRECT', Diabetes, Obesity and Metabolism, vol. 20, no. 6, pp. 1445-1452. https://doi.org/10.1111/dom.13250

HNF1A variant, energy-reduced diets and insulin resistance improvement during weight loss : The POUNDS Lost trial and DIRECT. / Huang, Tao; Wang, Tiange; Heianza, Yoriko; Sun, Dianjianyi; Ivey, Kerry; Durst, Ronen; Schwarzfuchs, Dan; Stampfer, Meir J.; Bray, George A.; Sacks, Frank M.; Shai, Iris; Qi, Lu.

In: Diabetes, Obesity and Metabolism, Vol. 20, No. 6, 01.06.2018, p. 1445-1452.

Research output: Contribution to journalArticle

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T1 - HNF1A variant, energy-reduced diets and insulin resistance improvement during weight loss

T2 - Diabetes, Obesity and Metabolism

AU - Huang, Tao

AU - Wang, Tiange

AU - Heianza, Yoriko

AU - Sun, Dianjianyi

AU - Ivey, Kerry

AU - Durst, Ronen

AU - Schwarzfuchs, Dan

AU - Stampfer, Meir J.

AU - Bray, George A.

AU - Sacks, Frank M.

AU - Shai, Iris

AU - Qi, Lu

PY - 2018/6/1

Y1 - 2018/6/1

N2 - Aim: To determine whether weight-loss diets varying in macronutrients modulate the genetic effect of hepatocyte nuclear factor 1α (HNF1A) rs7957197 on weight loss and improvement of insulin resistance. Materials and methods: We analysed the interaction between HNF1A rs7957197 and weight-loss diets with regard to weight loss and insulin resistance improvement among 722 overweight/obese adults from a 2-year randomized weight-loss trial, the POUNDS Lost trial. The findings were replicated in another independent 2-year weight-loss trial, the Dietary Intervention Randomized Controlled Trial (DIRECT), in 280 overweight/obese adults. Results: In the POUNDS Lost trial, we found that a high-fat diet significantly modified the genetic effect of HNF1A on weight loss and reduction in waist circumference (P for interaction =.006 and.005, respectively). Borderline significant interactions for fasting insulin and insulin resistance (P for interaction =.07 and.06, respectively) were observed. We replicated the results in DIRECT. Pooled results showed similar significant interactions with weight loss, waist circumference reduction, and improvement in fasting insulin and insulin resistance (P values for interaction =.001,.005,.02 and.03, respectively). Greater decreases in weight, waist circumference, fasting insulin level and insulin resistance were observed in participants with the T allele compared to those without the T allele in the high-fat diet group (P =.04,.03 and.01, respectively). Conclusions: Our replicable findings provide strong evidence that individuals with the HNF1A rs7957197 T allele might obtain more benefits in weight loss and improvement of insulin resistance by choosing a hypocaloric and high-fat diet.

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SN - 1462-8902

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